Transformation of resveratrol under disinfection conditions Elena A. Detenchuk a , Polonca Treb  se b , Aleksandra Marjanovi  c c , Dmitry S. Kosyakov d , Nikolay V. Ul’yanovskii d , Mojca Bavcon Kralj b, ** , Albert T. Lebedev a, * a Moscow State University, Department of Chemistry, Moscow, Russia b University of Ljubljana, Faculty of Health Sciences, Ljubljana, Slovenia c University of Sarajevo, Faculty of Pharmacy, Sarajevo, Bosnia and Herzegovina d Northern Arctic Federal University, Arkhangelsk, Russia highlights graphical abstract  Trans-resveratrol becomes more and more popular all over the world as a powerful antioxidant.  The first study of transformation of resveratrol and its formulations in aquatic chlorination.  Over 80 transformation products were tentatively identified using GC- HRMS and UPLC-HRMS.  Toxicity estimation of resveratrol products was carried out using luminescent bacteria V. fischeri. article info Article history: Received 27 April 2020 Received in revised form 10 June 2020 Accepted 26 June 2020 Available online 8 July 2020 Handling Editor: Keith Maruya Keywords: Trans-resveratrol Aquatic chlorination Disinfection by-products GC-HRMS LC-HRMS Toxicity abstract Trans-resveratrol becomes more and more popular all over the world as a powerful antioxidant. Since its positive properties, including antioxidant, anti-inflammatory, anti-tumor are indisputable, nowadays trans-resveratrol is used as a component of various products from nutriceutics to body care formulations, where it is supposed to behave as natural antioxidant and anti-aging compound. It is also added to food packaging materials to increase their stability or/and prevent oxidation. Nevertheless, being released to the environment resveratrol easily forms various transformation products with potentially negative environmental and health effects. The present paper deals with transformation of pure resveratrol and its formulation used as UV-protectors in conditions of aquatic chlorination. Over 80 transformation products were tentatively identified using gas chromatography-high resolution mass spectrometry (GC-HRMS) and ultra pressure liquid chromatography-high resolution mass spectrometry (UPLC-HRMS). Chlorinated phenols and biphenyls are the most relevant among them. Estimation of toxicity of resveratrol products was carried out using luminescent bacteria V. fischeri tests. © 2020 Elsevier Ltd. All rights reserved. 1. Introduction Photons of UV light cause breakage of covalent bonds and thus induce different oxidation processes leading to aging and weath- ering of different construction materials, coatings, plastics, rubber, etc. UV-radiation is particularly harmful for biological systems, causing damage to skin cells, resulting in accelerated aging of the * Corresponding author. ** Corresponding author. E-mail addresses: mojca.kralj@zf.uni-lj.si (M.B. Kralj), a.lebedev@org.chem.msu. ru (A.T. Lebedev). Contents lists available at ScienceDirect Chemosphere journal homepage: www.elsevier.com/locate/chemosphere https://doi.org/10.1016/j.chemosphere.2020.127557 0045-6535/© 2020 Elsevier Ltd. All rights reserved. Chemosphere 260 (2020) 127557