Assessment of Renal Hemodynamics and Function in Pigs with 64-Section Multidetector CT: Comparison with Electron-Beam CT 1 Elena Daghini, MD Andrew N. Primak, PhD Alejandro R. Chade, MD James D. Krier, MS Xiang-Yang Zhu, MD Erik L. Ritman, MD, PhD Cynthia H. McCollough, PhD Lilach O. Lerman, MD, PhD Purpose: To prospectively evaluate the feasibility of obtaining reli- able measurements of renal hemodynamics and function by using 64-section multidetector CT. Materials and Methods: This study was approved by the Institutional Animal Care and Use Committee. Eight pigs (two with induced unilat- eral renal artery stenosis) were studied with both electron- beam CT and 64-section multidetector CT at 1-week inter- vals in randomized order. Both kidneys were scanned repeatedly, without table movement, for about 3 minutes after intravenous (IV) administration of a bolus of contrast medium and again during vasodilator challenge (acetylcho- line). Images were reconstructed on each CT console but were analyzed on the same independent workstation. At- tenuation changes in the kidneys were plotted as function of time, and time-attenuation curves (TACs) were subse- quently analyzed to determine regional perfusion and vol- ume, glomerular filtration rate (GFR), and renal blood flow (RBF). Statistical analysis utilized Student t test, analysis of variance (ANOVA), linear regression, and Bland-Alt- man analysis. Results: TACs obtained with multidetector CT were qualitatively similar to those obtained with electron-beam CT, as were the quantitative values of renal perfusion and function. RBF correlated significantly between the two techniques (RBF MD = 0.96  RBF EB mL/min; R = 0.77, P  .01). GFR MD was also similar to GFR EB (77.6  8.3 vs 79.8  8.8 mL/min, p  .05). Bland-Altman plots showed good agreement between the two techniques. Both techniques similarly detected the differences between stenotic and contralateral kidneys. Conclusion: The clinical multidetector CT scanner provides reliable measurements of single-kidney hemodynamics and func- tion, which are similar to those obtained with previously validated electron-beam CT.  RSNA, 2007 1 From the Department of Medicine, Divisions of Nephrol- ogy and Hypertension (E.D., A.R.C., J.D.K., X.Y.Z., L.O.L.) and Cardiovascular Diseases (L.O.L.), Department of Radi- ology (A.N.P., C.H.M.), and Department of Physiology and Biomedical Engineering (E.L.R.), Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905. From the 2005 RSNA Annual Meeting. Received April 13, 2006; revision requested June 21; revision received July 1; ac- cepted August 2; final version accepted October 16. Sup- ported in part by National Institutes of Health grants DK- 73608, HL-77131, and HL-72255; American Heart Asso- ciation; an Award for Research in Cardiology (ARC) from the Division of Cardiovascular Disease, Mayo Clinic Col- lege of Medicine; and University of Study of Pisa, Italy. C.H.M., A.N.P. supported in part by grants from Siemens Medical Solutions. C.H.M. and A.N.P. supported in part by a grant from GE Healthcare. Address correspondence to L.O.L. (e-mail: lerman.lilach@mayo.edu ).  RSNA, 2007 ORIGINAL RESEARCH  EXPERIMENTAL STUDIES Radiology: Volume 243: Number 2—May 2007 405 Note: This copy is for your personal non-commercial use only. To order presentation-ready copies for distribution to your colleagues or clients, contact us at www.rsna.org/rsnarights.