IJSRST17337 | Received : 01 March-2017 | Accepted : 08- March -2017 | March-April - 2017 [(3)2: 05-11 ] © 2017 IJSRST | Volume 3 | Issue 3 | Print ISSN: 2395-6011 | Online ISSN: 2395-602X Themed Section: Science and Technology 5 Synthetic Nitrogen-containing Polymers and their Application as Copper Supports in Click Chemistry Hallan Bruno de Matos Angeira Gomes 1 , Cristiane Aragão de Souza Bastardis 1 , Thays Pontes de Freitas 1 , Pedro Ivo Canesso Guimarães, 1 Ayres Guimarães Dias,* 1 Jorge Luiz de Oliveira Domingos *1 * 1 Lab. de Química Orgânica, Instituto de Química, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil jlo.domingos@gmail.com 1 ABSTRACT Two nitrogen-containing polymers were synthesized and used as support for CuSO 4 to evaluate their catalytic activity in 1,3-heterodipolar cycloaddition reactions (1,3-DC) of benzylazide and ethyl propiolate. Polyvinylimidazole (PVI-DVB) was obtained by vinylimidazole polymerization with divinylbenzene and polystyryl pyridine (PSP) was prepared by condensation of lutidine and terephtaldehyde and with collidine as the reticulating agent. The activity was measured by titration with staNdard HCl solution, and PVI-DVB showed 4.6 mEg/g and PSP 0.7 mEg/g polymer. Impregnation with copper was possible by stirring the polymers in aqueous CuSO 4 solution. PSP fixed less copper (~0.2 %) than PVI-DVB that fixed thirty times more (6.2 %). The 1,3-DC under microwave irradiation, in the presence of PSP-Cu or PVI-DVB-Cu, gave origin to quantitative yields of the triazoles, and 1,4 regioisomer was the main product. By reusing the copper supported (4X), no changes in yields were observed, only a small decrease in regioselectivity. Keywords: Polyvinylimidazole Divinylbenzene, Polystyryl Pyridine, Copper Supported, Click Chemistry I. INTRODUCTION The methodology of ‘solid phase’ synthesis was first described in the literature by Merrifield and since then the use of this approach in organic preparations has expanded from laboratorial protocols to industrial processes. 1 Solid supported reagents are easily removed from reactions by filtration and recycling of recovered reagents is economical, environment-friendly and efficient. Metal supported polymers have been successfully employed in various catalytic processes and the presence of heterochain polymers containing functional groups of electron pair donors, such as carboxyl, hydroxyl, amino derivative groups, sulfur and phosphorus can be used to attach metals onto the surface of polymers. 2 Nitrogen- containing heterocyclic compounds are an important class of metal ligands and polymers containing these groups have been used as a support in the preparation of organic catalysts. Polyvinylpyridines (PVPY) 3 and poly- N-vinylimidazole (PVI) 4 are the most representative members of this group. PVPY are interesting polymer ligands which can act as catalytic supports and the presence of nitrogen atoms in different positions in relation to the main chain affects their complexing ability and hence, should influence their catalytic activity. 3 Kureshy et al. studied supported manganese salen complexes on 4-vinylpyridine reticulated with DVB and described as a powerful catalyst in the enantioselective epoxidation of styrene. 5 Spinelli et al. reported the ability of poly(4- vinylpyridine) films to protect copper corrosion at acid pH. These films managed to impart a significant level of corrosion resistance to the copper samples and almost 100% efficiency was reached employing this methodology. 6 PVI was used by Breslow et al. as an enzyme mimetic in