A gene essentiality signature for studying the mechanism of action of drugs Wenyu Wang 1 *, Jie Bao 1 , Shuyu Zheng 1 , Shan Huang 2 , Jehad Aldahdooh 1 , Yinyin Wang 1 , Johanna Eriksson 1 , Ziaurrehman Tanoli 1 , Jing Tang 1* 1. Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki 00290, Finland 2. Department of Radiation Oncology, Second Affiliated Hospital, Xi’an Jiaotong University, No.157, Xi Wu Road, Xi’an, 710004, Shaanxi, China *Corresponding author . CC-BY-NC-ND 4.0 International license perpetuity. It is made available under a preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in The copyright holder for this this version posted November 8, 2022. ; https://doi.org/10.1101/2022.11.07.514541 doi: bioRxiv preprint