Research Article A Nanostructured Cu(II) Coordination Polymer Based on Alanine as a Trifunctional Mimic Enzyme and Efficient Composite in the Detection of Sphingobacteria Noelia Maldonado , 1 Ana Latorre , 2 F´ elix Zamora , 1,3 ´ Alvaro Somoza , 2 Carlos J. G´ omez-Garc´ ıa , 4 Agatha Bastida , 5 and Pilar Amo-Ochoa 1,3 1 Departamento de Qu´ ımica Inorg´ anica, Universidad Aut´ onoma de Madrid, Madrid 28049, Spain 2 Instituto Madrileño de Estudios Avanzados en Nanociencia (IMDEA Nanociencia), Cantoblanco, Madrid 28049, Spain 3 Institute for Advanced Research in Chemical Sciences (IAdChem), Universidad Aut´ onoma de Madrid, Madrid 28049, Spain 4 Departamento de Qu´ ımica Inorg´ anica, Universidad de Valencia, C/Dr. Moliner 50 46100 Burjasot, Valencia, Spain 5 Departamento de Qu´ ımica Bio-Org´ anica, Instituto de Qu´ ımica Org´ anica General del CSIC, Madrid 28006, Spain Correspondence should be addressed to Agatha Bastida; agatha.bastida@csic.es and Pilar Amo-Ochoa; pilar.amo@uam.es Received 27 January 2022; Accepted 29 March 2022; Published 11 April 2022 Academic Editor: Patrick Bednarski Copyright © 2022 Noelia Maldonado et al. is is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. is research raises the potential use of coordination polymers as new useful materials in two essential research fields, allowing the obtaining of a new multiartificial enzyme with the capacity to inhibit the growth of bacteria resistance. e fine selection of the ligands allows the design of a new 2D coordination polymer (CP), with the formula [Cu 2 (IBA) 2 (OH 2 ) 4 ] n ·6nH 2 O, by the combination of Cu (II) as the metal center with a pseudoamino acid (H 2 IBA � isophthaloyl bis β-alanine). Quantitative total X-ray fluorescence (TXRF) analyses show that the obtained CP can gradually release Cu (II) ions. Additionally, this CP can be nanoprocessed and transformed into a metal-organic gel (MOG) by using different Cu (II) salt concentrations and the application of ultrasounds. Considering its nanometric dimensions, the slow Cu (II) release and its simple processability, its performance as an artificial enzyme, and its antibacterial ability were explored. e results obtained show the first nanocoordination polymer acting as an artificial multienzyme (peroxidase, catalase, and superoxodismutase) exhibiting antibacterial activity in the presence of hydrogen peroxide, with selective behavior for three bacterium strains (S. spiritovirum, A. faecales, and B. cereus). Indeed, this CP shows a more robust inhibition capacity for Sphingobacterium. Going beyond that, as there are no comfortable and practically clinical tests capable of detecting the presence of Sphingobacteria, the compound can be easily embedded to form moldable gelatin that will facilitate the handling and low-cost commercial kits. 1. Introduction Pathogenic intracellular bacteria have been proven to trigger numerous chronic or recurrent infectious diseases that pose substantial global public health threats. e main medical route for treating bacteria is antibiotics, but these micro- organisms use many mechanisms to survive by becoming resistant [1]. For this reason, the discovery and development of alternative antimicrobial strategies are also critical [2–6]. Additionally, in the last decades, researchers have tried intensively to find new compounds capable of behaving as artificial enzymes, copying the functions of natural enzymes [7]. ese artificial enzymes will be able to produce essential chemicals on an industrial scale with a performance that rivals their natural counterparts. Moreover, if we are in- spired by the use that the human body makes of enzymes to improve its defense mechanisms, see, for example, the xanthine oxidase that can generate superoxide anion (O − 2 ) and H 2 O 2 in the presence of O 2 , or the myeloperoxidase that can catalyze the conversion of H 2 O 2 into highly reactive oxygen species (ROS) that behave as natural antimicrobials, then artificial enzymes could also be used as alternative Hindawi Bioinorganic Chemistry and Applications Volume 2022, Article ID 8788221, 10 pages https://doi.org/10.1155/2022/8788221