1740 Josephs et al.: Journal of aoaC InternatIonal Vol. 102, no. 6, 2019 Special GueSt editor Section Guest edited as a special report on “Mycotoxins and Food Safety-Prevention and Control: Expectation and Reality” by Kai Zhang and Melissa Phillips. We would like to thank the National Key R&D Program of China for funding support (No. 2016YFE026500). All NMR and LC studies were carried out by the coauthors of this document in the course of secondments at the BIPM. The support of the parent institution of each scientist in making them available for secondment to the BIPM is gratefully acknowledged. Bruno Garrido wishes to acknowledge funding for his secondment from the Brazilian Ministry of Education under the Coordination for the Improvement of Higher Education Personnel (CAPES) post-doctoral scholarship program (process: 99999.007374/2015-01). The BIPM Mycotoxin Metrology Capacity Building and Knowledge Transfer Program: Accurate Characterization of a Pure Afatoxin B 1 Material to Avoid Calibration Errors Ralf D. Josephs Bureau International des Poids et Mesures (BIPM), Département de Chimie, Pavillon de Breteuil, 92312 Sèvres Cedex, France Xiaomin li, Xiuqin li, and Zhen Guo NIM, Division of Chemical Metrology & Analytical Science, Beijing, 100029, People’s Republic of China BRuno GaRRiDo INMETRO, Chemical and Thermal Metrology Division, Duque de Caxias, Brazil ilkeR un TUBITAK UME, Chemistry Group Laboratories, PO Box 54, 41470, Gebze-Kocaeli, Turkey aDeline DaiReauX, Tiphaine ChoTeau, GusTavo maRTos, and sTeven WesTWooD Bureau International des Poids et Mesures (BIPM), Département de Chimie, Pavillon de Breteuil, 92312 Sèvres Cedex, France honGmei li NIM, Division of Chemical Metrology & Analytical Science, Beijing, 100029, People’s Republic of China RoBeRT i. WielGosZ Bureau International des Poids et Mesures (BIPM), Département de Chimie, Pavillon de Breteuil, 92312 Sèvres Cedex, France DOI: https://doi.org/10.5740/jaoacint.19-0144 Background: the contamination of food and feed by mycotoxins, Afatoxin B 1 (AfB 1 ) being one of the most prominent examples, is of imminent concern to many countries. regulatory limits for mycotoxins have been implemented, and these need to be supported by a sound measurement infrastructure for mycotoxin analysis in order to enforce and verify products, protect populations, and avoid technical barriers to trade in food stuffs. Objective: A Capability Building and Knowledge transfer program on Metrology for Safe Food and Feed in Developing Economies was started at the International Bureau of Weights and Measures to allow National Metrology Institutes or Designated Institutes to work together to strengthen their national mycotoxin metrology infrastructure. Methods: Knowledge transfer to scientists is provided to enable the characterization of selected pure mycotoxin materials and the production of corresponding certifed reference material solutions. Results: this higher-order measurement capability Supplemental information is available on the J. AOAC Int. website, http://aoac.publisher.ingentaconnect.com/content/aoac/jaoac Corresponding author’s e-mail: ralf.josephs(at)bipm.org can in turn support mycotoxin testing laboratories within their countries through the provision, for example, of standard solutions of critical analytes that are traceable to the international System of units (Si). Conclusions and Highlights: the purity characterization and value assignment for a high- purity AfB 1 material (979.6 ± 2.3 mg/g, k = 2) intended to be used for the gravimetric production of Si traceable calibration solutions for AfB 1 is described using an approach combining quantitative nMr and lc–diode array detection–tandem MS for the correction of the mycotoxin-related impurity content. T he International Bureau of Weights and Measures (BIPM) Capability Building and Knowledge Transfer (CBKT) program on Metrology for Safe Food and Feed in Developing Economies concentrates on and was developed in response to the demands to improve metrological capabilities for food and feed analysis in the developing world. The issue of food safety and trade is a key concern for countries developing metrology and QA systems. Ensuring the safety of food is a main focus of continuing international and national action. The frequent contamination of food and feed by mycotoxins, toxic natural secondary metabolites formed by fungi, are of particular concern, as it can have serious adverse effects on humans and animals. More than 100 countries have implemented specifc regulatory limits for mycotoxins in food and feed to safeguard the health of humans and the economic interests of producers and traders (1). The regulatory limits for mycotoxins need to be supported by a frm measurement infrastructure for mycotoxin analysis in order to enforce and verify products, protect populations, and avoid technical barriers to trade in food and feed. Selected System of Units (SI)-traceable value assigned pure mycotoxin materials and corresponding calibrator solutions Downloaded from https://academic.oup.com/jaoac/article/102/6/1740/5658329 by guest on 09 February 2023