Journal Pre-proofs Trypanocidal activity of new 1,6-diphenyl-1H-pyrazolo[3,4-b]pyridine deriv- atives: Synthesis, in vitro and in vivo studies Joana L.S. Ribeiro, Júlio C.A.V. Soares, Gisele B. Portapilla, Maiara V. Providello, Camilo H.S. Lima, Estela M.F. Muri, Sérgio de Albuquerque, Luiza R.S. Dias PII: S0968-0896(20)30685-4 DOI: https://doi.org/10.1016/j.bmc.2020.115855 Reference: BMC 115855 To appear in: Bioorganic & Medicinal Chemistry Received Date: 3 August 2020 Revised Date: 15 October 2020 Accepted Date: 1 November 2020 Please cite this article as: J.L.S. Ribeiro, J.C.A. Soares, G.B. Portapilla, M.V. Providello, C.H.S. Lima, E.M.F. Muri, S.d. Albuquerque, L.R.S. Dias, Trypanocidal activity of new 1,6-diphenyl-1H-pyrazolo[3,4-b]pyridine derivatives: Synthesis, in vitro and in vivo studies, Bioorganic & Medicinal Chemistry (2020), doi: https:// doi.org/10.1016/j.bmc.2020.115855 This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. © 2020 Published by Elsevier Ltd.