Bhat et al Journal of Drug Delivery & Therapeutics. 2021; 11(1-s):170-172 ISSN: 2250-1177 [170] CODEN (USA): JDDTAO Available Online on 15.02.2021 at http://Jddtonline.Info Journal Of Drug Delivery and Therapeutics Open Access to Pharmaceutical and Medical Research © 2011-21, Publisher and Licensee JDDT, This is an Open Access Article which Permits Unrestricted Non-Commercial Use(Cc By-Nc), Provided the Original Work is Properly Cited Open Access Full Text Article Review Article Medicinal benefits and scientific justification of Commiphora mukul (Muqil): A review Shabir Ahmad Bhat* 1 , Shameem Ahmad Rather 2 1. MD Scholar Department of Moalajat, Regional Research Institute of Unani Medicine, Naseem Bagh, University of Kashmir, Srinagar J&K, India 2. Reader Department of Moalajat, Regional Research Institute of Unani Medicine, Naseem Bagh, University of Kashmir, Srinagar J&K, India Article Info: _____________________________________________ Article History: Received 07 Dec 2020; Review Completed 23 Jan 2021 Accepted 29 Jan 2021; Available Online 15 Feb 2021 _____________________________________________ Cite This Article As: Bhat SA, Rather SA, Medicinal Benefits and Scientific Justification of Commiphora mukul (Muqil): A Review, Journal Of Drug Delivery And Therapeutics. 2021; 11(1- S):170-172 Doi: http://dx.doi.org/10.22270/jddt.v11i1-s.4550 Abstract ____________________________________________________________________________________________________ Commiphora mukul (Muqil or Guggul), oleo-gum, has been in use for thousands of years as a medicine in Unani and Ayurvedic medicinal systems. It was primarily used for swellings, inflammation, piles, arthritis and urinary disorders. Among its various types Muqil-I-Arzaq, a gum, having reddish hue is considered to be the best form of Muqil for medicinal purposes. It has been revealed to inhibit the nuclear factor-kb, a regulator of inflammatory response, and act as a potent antagonist to the receptors of androgens, mineralocorticoides, and glucocorticoides. Muqil is a versatile herb with diverse medicinal benefits which demand scientific validation. A coherent review of properties, medicinal benefits, traditional uses and scientific studies of Muqil, along with the overall processes involved from collection to consumption is judiciously described in this paper. The aim of this review is to provide a base for multiple research works, validating Commiphora mukul in different chronic ailments. keywords: Commiphora mukul, Inflammation, Muqil, Nuclear factor-KB, Unani *Address for Correspondence: Shabir Ahmad Bhat, MD Scholar, Department of Moalajat, Regional Research Institute of Unani Medicine, Naseem Bagh, University of Kashmir, Srinagar, Jammu &Kashmir, India. Introduction Commiphora mukul (Muqil in Arab) is oleo gum of a small tree, which mostly grows in Arab countries. The plant is commercially cultivated in India and Pakistan. It is widely used as medicine for different diseases in Unani and Ayurvedic system of medicines. It is of many types, Muqil-i- Arzaq, Muqilul yahūd, Muqil-i-Saqalbi and Muqil-i-Makki. Except the last one which is a fruit, all other types are gum (Gond). Among all these types Muqil-i-Arzaq, having reddish hue, is considered to be the best form of Muqil. It dissolves in water easily and its life span is about 20 years. 1 Because of its over harvesting in India, world conservation union has kept it in red list of threatened species. 2 In Greco-Arab (Unani) medicinal system muqil is one of the versatile medicinal herb having wide range of properties. Some of which have been scientifically evaluated, yet much of them are still under curtains. Taxonomical classification and nomenclature 3,4,5 Kingdom: Plantae Order: Spindales Family: Burseraceae Genus: Commiphora Botanical name: Commiphora mukul Synonym: Commiphora wightii, Balsamodendron mukul Vernacular names 1,3,4,5 English: Indian bdellium, Gum Guggul Arabic: Muqil, Qafr Persian: Bu-i-jahudān Greek: Madīqūn, Aflatin, Fadīlūn Roman: Bazaliūn Hindi: Guggul Sanskrit: Devadhupa, Kaushika Bengali: Gugal, Gugu Gujarati: Gugali, Gugar Tamil: Erumaikan, Kungiliyam General description Macroscopic description Muqil tree grows up to 4 m tall, densely branched, having simple or trifoliate leaves, with serrated margins. The plant has separate male and female flowers, so that it reproduces