IOSR Journal Of Humanities And Social Science (IOSR-JHSS) Volume 23, Issue 6, Ver. 7 (June. 2018) PP 82-90 e-ISSN: 2279-0837, p-ISSN: 2279-0845. www.iosrjournals.org DOI: 10.9790/0837-2306078290 www.iosrjournals.org 82 | Page Palliative Chemotherapy and Ibandronic Acid Improves Quality Of Life of Bone Metastasis Breast Cancer Patients Pamula, Arshybhara Fikri 1 . Susilo, Hery 2 . 1 Surgery Resident of Saiful Anwar General Hospital Malang - Faculty of Medicine Brawijaya University Malang 2 Oncology Surgery Deparment of Saiful Anwar General Hospital Malang - Faculty of Medicine Brawijaya University Malang Corresponding Author: Pamula, Arshybhara Fikri --------------------------------------------------------------------------------------------------------------------------------------- Date of Submission: 09-06-2018 Date of acceptance: 26-06-2018 --------------------------------------------------------------------------------------------------------------------------------------- I. BACKGROUND In Indonesia, the prevalence of cancer is quite high. Based on Basic Health Research data of 2013, the prevalence of cancer in Indonesia is 1.4 per 1000 population, or about 330,000 people. The highest cancer in Indonesia in women is breast cancer and cervical cancer. Based on data of Hospital Information System 2010, 12,014 cases of breast cancer cases (28,7%), cervical cancer 5,349 cases (12,8%). Cancer cells can break away from the original tumor and spread to other parts of the body. This can happen by lymph or the circulatory system. Bone metastases are a common complication of cancer patients, occurring in 70% of patients with advanced cancer. Bone metastases can cause severe pain, pathologic fractures, menopausal hypercalcaemia and the risk of spinal cord. Bone metastases are a serious complication and require high medical costs. Chemotherapy is a treatment process by using drugs intended to destroy or slow the growth of cancer cells. The side effects of chemotherapy arise because chemotherapy drugs not only destroy cancer cells also attack healthy cells, especially distractions that heal quickly. Chemotherapy side effects that attack blood cell counts in the leukocyte marrow, erythrocytes, and platelets. This will increase the chances of getting infected, bruising and bleeding easily, and pregnancy. In addition, the side effects are nausea, vomiting, hair loss, mouth ulcers, appetite drop, diarrhea, constipation, menstrual changes, and eye disorders . To increase the rate of destruction and excessive bone formation due to metastasis. A study with intravenous administration of intravenous ibandronate for 96 weeks at 3-4 weeks interval was significantly improve the quality of life as well as effective and well tolerated palliative therapy in patients with bone metastases breast cancer. The impact of breast cancer on quality of life shows that breast cancer sufferers feel helplessness, imperfect, embarrassed by breast shape changes, unhappy, unattractive, feelings of unacceptable acceptance by others, isolation, fear, grief, lingering in bed , functional disability, failing to meet family needs, lack of sleep, difficulty concentrating, anxiety, and depression. Quality of life is an individual's perception of one's life according to the cultural context and value system it embraces, including its life goals, hopes and intentions.8 Currently, attention is devoted to developing quality of life among cancer survivors. The prevalence rate of depression increases with the development of cancer, from 11% in the early stages, and develops up to 50% in patients with metastatic breast cancer who are undergoing palliative therapy.. II. METHODE This study was an observational study with a cohort approach. Which aims to find a palliative chemotherapy relationship to the quality of life of patients with advanced breast cancer. The research was conducted in Oncology Polyclinic of Saiful Anwar Hospital Malang, conducted between July 2015 until July 2016. The population of this study subjects were all breast cancer patients with clinically suspicious bone metastases and conducted bone survey obtained a description of bone metastases requiring palliative chemotherapy as well as therapy of Ibandronic Acid and treatment to Polyclinic Oncology Hospital Saiful Anwar Malang. In this study there is one group of bone metastases breast cancer patients according to inclusion criteria and exclusion criteria. Each patient was given informed consent and obtained ethical clearance from Health Research Ethics Committee of Brawijaya University Malang / Saiful Anwar Hospital Malang. The number of