~ 29 ~ International Journal of Herbal Medicine 2017; 5(4): 29-32 E-ISSN: 2321-2187 P-ISSN: 2394-0514 IJHM 2017; 5(4): 29-32 Received: 16-05-2017 Accepted: 17-06-2017 K. Md. F. Rahiman Siddiqui PG Scholar, Department of Moalajat, National Institute of Unani Medicine, Bengaluru, Karnataka, India Mohd. Aleemuddin Quamri Reader, Department of Moalajat, National Institute of Unani Medicine, Bengaluru, Karnataka, India MA Siddiqui Prof, Department of Moalajat, National Institute of Unani Medicine, Bengaluru, Karnataka, India Md. Anzar Alam Ph.D Scholar, Department of Moalajat, National Institute of Unani Medicine, Bengaluru, Karnataka, India Hamiduddin Lecturer, Dept. of Ilmul Saidla, National Institute of Unani Medicine, Bengaluru, Karnataka, India Correspondence K. Md. F. Rahiman Siddiqui PG Scholar, Department of Moalajat, National Institute of Unani Medicine, Bengaluru, Karnataka, India Efficacy of Unani formulation and Roghan-e-Dhatura in Adhesive Capsulitis: An open labeled interventional study K. Md. F. Rahiman Siddiqui, Mohd. Aleemuddin Quamri, MA Siddiqui, Md. Anzar Alam and Hamiduddin Abstract Background and Objectives: Adhesive Capsulitis (AC) is commonly known as Frozen Shoulder Syndrome (FSS) is a condition characterized by intense shoulder pain, gradual fibrosis of the glenohumeral joint that causes a limited range of motion, and contracture of the glenohumeral joint capsule. The disease peaks between 40 and 70 years of age and 10 to 36% of the individuals with Diabetes mellitus are mostly affected followed by Hypothyroidism and Hyperthyroidism. In conventional medicine it is being treated with pharmacologically, non-pharmacologically and with surgery. In Unani system of medicine AC is considered as a type of articular disease and treated according to the principles of Amraz-e-Mafasil with drugs and regimens. In this study a Unani formulation and Roghan-e- Dahtura is selected to validate its indication as effective in painful joints. Methods: This study was conducted as an open labeled interventional without control pre and post analysis on 30 patients with oral Unani formulation (Sibr, Halela Zard, Suranjan Sheerin, Saqmooniya and Aabe Mako) and local application of Roghan-e-Dhatura for 28 days with follow ups on, 7 th , 14 th , 21 th and 28 th day. The pre and post treatment effects were assessed objectively with VAS, SPADI. Results: The study outcome measured with mean and standard deviation in VAS, before treatment 8.33±0.55 and after treatment 2.23±0.73, with p value < 0.001 and SPADI 76.51±2.80 and 16.61±6.87, found statistically highly significant with p value <0.001 with Tukey-Kramer Multiple comparisons and Kruskal-Wallis tests. Interpretation & Conclusion: This study shows clinically and statistically significant difference in ameliorating the symptoms of adhesive capsulitis without any adverse effect. Therefore, it can be concluded that the test drugs are safe and effective in management of adhesive capsulitis symptoms. Keywords: Adhesive Capsulitis, Frozen Shoulder Syndrome, Unani Formulation, Roghan-e-Dhatura, Wajaul Mafasil, VAS, SPADI 1. Introduction Adhesive Capsulitis (AC) results in progressive painful restriction in range of movement and can reduce function and quality of life [1] . Adhesive Capsulitis commonly known as Frozen Shoulder Syndrome (FSS) and also called pericapsulitis, periarthritis, adherent bursitis, obliterative bursitis, shoulder periarthritis, scapulo-humeral periarthritis, adherent subacromial bursitis, hypomobile syndrome [2, 3] . The term “frozen shoulder” commonly used to describe adhesive capsulitis and it is often self-limited, it can persist for years and may never fully resolve [4] . This disorder is one of the most common musculoskeletal problems seen in orthopedics [5] . The prevalence of adhesive capsulitis affects 2 to 3 % of the population [6] . It is more in women with a peak age of onset of 56 years and 15 % of patients develop bilateral disease [7] . The etiopathology of this disease remains unclear and understanding of pathogenesis is increasing. [8,9] Psychological factors, metabolic disorders (diabetes, obesity), older age and female gender may also be associated with frozen shoulder syndrome [10,11] . AC is commonly treated with non-steroidal anti-inflammatory drugs (NSAIDs) [5] . However, NSAIDs are associated with serious gastrointestinal adverse effects which limit their use in many patients [12] . Other drugs like opioids and non-opioid analgesics and intra-articular steroids may not be effective in all patients [13] . Hence, there is a need for searching of effective and safe drugs for the treatment of AC. Adhesive Capsulitis can be literally termed in Arabic as Iltehabe La’siq ul Mahsoor, and this clinical condition is commonly known as Frozen Shoulder Syndrome (Waja ul Katif/ Mutalazima Munjamid al Katif). It is a restricted movement along with painful shoulder joint. In Unani literature the symptoms of Adhesive Capsulitis are met under the caption of Wajaul Mafasil. Wajaul Mafasil is a painful or inflammatory condition affecting joints, their surrounding muscle and ligaments [14, 15, 16, 17] .