Dr Jagdish Gupta et al JMSCR Volume 05 Issue 02 February 2017 Page 17804 JMSCR Vol||05||Issue||02||Pages 17804-17810||February 2017 Review Article Neuroendocrine Carcinoma of Stomach: A Case Report and Review of Literature Authors Dr Jagdish Gupta 1 , Dr Archit Gupta 2 , Dr Pankaj Chandel 3 , Dr Arun Gupta 4 , Dr Bhavesh Devkaran 5 , Dr Arun Chauhan 6 1,6 Assistant Professor, Dept of General Surgery, Indira Gandhi Medical College, Shimla, Himachal Pradesh 2,3 Post graduate student, Dept of General Surgery, Indira Gandhi Medical College, Shimla, Himachal 4,5 Professor, Department of General Surgery, Indira Gandhi Medical College, Shimla, Himachal Pradesh Corresponding Author Dr Archit Gupta Post Graduate Student, Dept of General Surgery, Indira Gandhi Medical College, Shimla, Himachal Pradesh Email: archit9th@gmail.com, Phone no: 9805189895 Abstract Neuroendocrine neoplasms are rare tumors of stomach. In stomach these usually arise from enterochro- maffin cells of Kulchitsky and can vary from benign to highly malignant tumors. These are divided into four distinct groups according to their clinicopathological behaviour. Type 1 are usually benign, are associated with chronic atrophic gastritis and carry a good prognosis. Type 2 are similar to type 1 in clinical presentation but metastatise in around 10-30% patients. Type 3 are sporadic, usually more than 2cm in size and need radical surgery. Type 4 are poorly differentiated, highly malignant tumors and carry a very poor prognosis. Here we present a case of type 3 neuroendocrine carcinoma of the stomach which was diagnosed postoperatively by histopathology and confirmed by immunohistochemistry. The patient underwent a total gastrectomy with splenectomy with distal pancreatectomy with roux en-y-oesophagojejunostomy. We present this case due to its rarity. Review of literature done to emphasise the types and treatment of these tumors. Keywords: Neuroendocrine neoplasms,clinicopathologic,immunohistochemistry. Introduction Neuroendocrine neoplasms of the stomach are rare tumors that account for less than 1% of gastric tumors. 1 These tumors mostly arise from enetrochromaffin like cells of the stomach and are divided into four distinct groups according to their clinicopathological behaviour. 2 Type 1 are associated with chronic atrophic gastritis and comprise almost 70-80% of neuroendocrine tumors of the stomach. 3 Type 2 are histologically similar to type 1 and is associated with Zollinger Ellison syndrome and multiple endocrine neoplasia. 1,4 Type 3 are sporadic tumors which are not usually associated with other gastric conditions. Type 4 are uncommon, usually single, poorly differentiated tumors. 5 www.jmscr.igmpublication.org Impact Factor 5.84 Index Copernicus Value: 83.27 ISSN (e)-2347-176x ISSN (p) 2455-0450 DOI: https://dx.doi.org/10.18535/jmscr/v5i2.99