_____________________________________________________________________________________________________ *Corresponding author: E-mail: jasnaagic88@hotmail.com; Journal of Pharmaceutical Research International 34(51A): 17-24, 2022; Article no.JPRI.92188 ISSN: 2456-9119 (Past name: British Journal of Pharmaceutical Research, Past ISSN: 2231-2919, NLM ID: 101631759) Does Nifuroxazide Enhance the Effect of Metronidazole Oral Administration in the Treatment of Clostridium difficile Infection? Jasna Rahimić a* , Ervin Alibegović b , Admir Kurtćehajić c , Lana Lekić d , Dino Alibegović e and Esmeralda Dautović a a Faculty of Pharmacy, University of Tuzla, Univerzitetska 8, Tuzla-75000, Bosnia and Herzegovina. b University Clinical Center Tuzla, Ulica Prof. Dr. Ibre Pašića, Tuzla-75000, Bosnia and Herzegovina. c Blue Polyclinic Tuzla, 3. Tuzlanske Brigade 7, Tuzla-75000, Bosnia and Herzegovina. d Faculty of Health Studies, University of Sarajevo, Stjepana Tomića 1, Sarajevo-71000, Bosnia and Herzegovina. e Faculty of Medicine, University of Tuzla, Univerzitetska 1, Tuzla-75000, Bosnia and Herzegovina. Authors’ contributions This work was carried out in collaboration among all authors. Authors JR and EA were in charge for project planning, implementing and conceived the original project idea. Author AK collected and sorted questionnaries from patients. Authors AK and DA worked out majority of technical details, calculations and statistical analysis. Author LL collected some datas for project and supervised the project. Author ED gave critical overview of the manuscript. Author JR wrote the manuscript with support from authors EA, LL and ED. All authors read and approved the final manuscript. Article Information DOI: 10.9734/JPRI/2022/v34i51A36444 Open Peer Review History: This journal follows the Advanced Open Peer Review policy. Identity of the Reviewers, Editor(s) and additional Reviewers, peer review comments, different versions of the manuscript, comments of the editors, etc are available here: https://www.sdiarticle5.com/review-history/92188 Received 12 July 2022 Accepted 23 September 2022 Published 27 September 2022 ABSTRACT Aims: To evaluate the efficacy of metronidazole monotherapy and modified therapy with metronidazole + nifuroxazidefor the for treatment of a mild form of Clostridium difficile infection (CDI). Study Design: A prospective, randomized, controlled clinical trial. Place and Duration of Study: University of Applied Sciences Tuzla in the period from June 2018 to June 2019. Methodology: Sixty patients were included in the study, divided into two groups. One group received standard therapy (metronidazole) for the treatment of a mild form of CDI, while the other Original Research Article