S1 Supporting Information: Structure-Based Library Design and Fragment Screening for the Identification of Reversible Complement Factor D Protease Inhibitors Anna Vulpetti, a* Stefan Randl, a †, Simon Rüdisser, a Nils Ostermann, a Paul Erbel, a Aengus Mac Sweeney, a †† Thomas Zoller, a Bahaa Salem, a Bernd Gerhartz, a Frederic Cumin, a Ulrich Hommel, a Claudio Dalvit, a Edwige Lorthiois, a Jürgen Maibaum. a a Novartis Institutes for BioMedical Research, Novartis Pharma AG, Novartis Campus, CH-4056 Basel, Switzerland *Corresponding author: To whom correspondence should be addressed. Tel: +41-61-3241016. E-mail: anna.vulpetti@novartis.com.