Atul Kumar et al JMSCR Volume 04 Issue 07 July Page 11384 JMSCR Vol||04||Issue||07||Page 11384-11391||July 2016 A Clinical Outcome of Dexamethasone therapy of Patients with Pyogenic Meningitis Authors Atul Kumar 1 , Md Izhar Alam 2 , Taskeen Ahmad Reza 3 , Shruti Sonal 4 , Kaushal Kumar Sinha 5 , Karan Bhargav 6 , Wasim Alam 7 1 Associate professor, Dept of Medicine, Katihar Medical College, Katihar, Bihar, India 2 Assistant professor, Dept of Pathology, Katihar Medical College, Katihar, Bihar, India 3 Assistant Professor, Dept of Medicine, Katihar Medical College, Katihar, Bihar, India 4,5,6,7 PGT, Department of Medicine, Katihar Medical College, Katihar, Bihar, India Corresponding Author Dr Atul Kumar Associate Professor, Dept of Medicine, Katihar, Medical College, Katihar, Bihar, India. Email: dratulkumarkmc@gmail.com Ph: +91 8227040025 ABSTRACT Objective: Observation of hastening effect of dexamethasone on recovery time and reductions of case fatality and neurological complications of pyogenic meningitis. Methodology: A total of 39 patients with pyogenic meningitis were considered on the basis of short clinical history and laboratory findings like, fever, headache, projectile vomiting, confusion/delirium, unconsciousness and neck rigidity and kerning’s sign, raised CSF pressure, presence of turbidity or purulent CSF with identification of bacteria on gram staining or culture of CSF, High CSF cell count (> 10 to < 10000 /Cumm) with neutrophilic predominance, Reduced CSF glucose level (<40mg%), Low CSF to blood glucose concentration ratio (<40 %), High CSF protein level (>50mg/dl). Results: Data was analyzed by using MS-Office software. Conclusions: Adjunctive dexamethasone therapy may improve the outcome of pyogenic meningitis in adolescent and adult patients. And the intensity of headache, vomiting and fever were also relieved by using dexamethasone therapy. Key words: pyogenic meningitis, dexamethasone therapy, clinical outcome. Introduction Acute Pyogenic (Bacterial) meningitis is a potentially life threatening disease that is an inflammation of the meninges and underlying subarachnoid cerebro-spinal fluid (CSF). Acute pyogenic meningitis and with its associated high morbidity and mortality remains a major health problem worldwide. At least 30 countries worldwide including the United States, have reported serious outbreaks of meningococcal meningitis in recent years. [1] www.jmscr.igmpublication.org Impact Factor 5.244 Index Copernicus Value: 83.27 ISSN (e)-2347-176x ISSN (p) 2455-0450 DOI: http://dx.doi.org/10.18535/jmscr/v4i7.33