Citation: Mahesh Chand. Solvent Free Synthesis of Biscoumarins. Arc Org Inorg Chem Sci 2(3)- 2018. AOICS. MS.ID.000139. DOI: 10.32474/AOICS.2018.02.000139. 204 Solvent Free Synthesis of Biscoumarins Mahesh Chand* *Department of Chemistry, University of Delhi, India Received: March 22, 2018; Published: April 03, 2018 *Corresponding author: Mahesh Chand, Department of Chemistry, University of Delhi, Delhi-110007, India, Email: UPINE PUBLISHERS Open Access L Archives of Organic and Inorganic Chemical Sciences Mini Review Introduction Coumarins are widespread in nature and have been reported to possess various biological and/or pharmacological properties. They are known to possess antibacterial, inhibitory activity on platelet aggregation, antiallergic, anti-inflammatory, antioxidant, anti insecticidal, antiviral, anticoagulant, anticancer, antifungal, anti-HIV and antibiotics. Coumarin [1] is a simple molecule and many of its derivatives have been known for more than a century [1] (Figure 1). Coumarins have multiple biological activities including disease prevention, growth modulation and anti-oxidant properties. Figure 1 Bis heterocyclic compounds also constitute an important class of biologically active molecules. Expected to possess enhanced bioactivity and could also be explore as important intermediates for constructing new molecules. Biscoumarin is among one of bis heterocyclic in literature which have shown lot of biological applications. 3,3’-Methylene bis(4-hydroxycoumarin) commonly known as dicoumarol [2], occurs naturally and is the hemorrhagic agent responsible for sweet clover disease of cattle and has also been employed for the prevention and treatment of thrombosis [2] (Figure 2). Figure 2 Dicoumarol is also the starting material for the synthesis of furocoumarins and benzopyrans [3]. 3, 3-(4-Arylmethylene) bis- (4-hydroxycoumarins), commonly known as biscoumarins, which are the bridged substituted dimmers of 4-hydroxy Coumarin, have enormous potential as anticoagulants. Coumarin have become the research hot point based on their different pharmalogical profiles specially biscoumarin. Herein, we have made efforts to summarize the synthesis of bis (Coumarin) methane’s in solvent free conditions because solvent-free synthesis is gaining importance as a tool for the synthesis of a wide variety of useful and important compounds, Abstract Coumarin and Coumarin-related compounds are major source of interest for many of medicinal chemist to explore its various pharmacological potentials especially bis-coumarin for their anticoagulant activity. A number of reports have appeared in the literature on the enhancement of bioactivity of bis heterocyclic compounds over simple heterocyclic compounds. Biscoumarin are very well known and possess better biological activities like anticoagulant, anti oxidant, antimicrobial activity, anti cancerous and analgesic activity than the parent nuclei. Hence, realizing the importance of biscoumarin, we thought to summarize the synthesis of bis-coumarins under solvent-free conditions in this review. ISSN: 2637-4609 DOI: 10.32474/AOICS.2018.02.000139