Hindawi Publishing Corporation BioMed Research International Volume 2013, Article ID 787981, 7 pages http://dx.doi.org/10.1155/2013/787981 Research Article Mulberry Leaf Reduces Oxidation and C-Reactive Protein Level in Patients with Mild Dyslipidemia Pornanong Aramwit, 1 Ouppatham Supasyndh, 2 Tippawan Siritienthong, 1 and Nipaporn Bang 1 1 Bioactive Resources for Innovative Clinical Applications Research Unit, and Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Phayaai Road, Phatumwan, Bangkok 10330, ailand 2 Division of Nephrology, Department of Medicine, Phramongkutklao Hospital and College of Medicine, Bangkok 10400, ailand Correspondence should be addressed to Pornanong Aramwit; aramwit@gmail.com Received 3 October 2012; Revised 17 December 2012; Accepted 31 December 2012 Academic Editor: Joseph Fomusi Ndisang Copyright © 2013 Pornanong Aramwit et al. is is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. C-reactive protein (CRP) is the in�ammatory marker that could represent the in�ammation in blood vessels resulted from dyslipidemia. e objective of this study was to evaluate the antioxidative activity of mulberry leaf powder using DPPH assay and the effect of mulberry leaf powder on lipid pro�le, CRP level, and antioxidative parameters in mild dyslipidemia patients. A within- subjects design was conducted and patients received three tablets of 280 mg mulberry leaf powder three times a day before meals for 12 weeks. Total of 25 patients were enrolled but one subject was excluded. Aer three months of mulberry leaf consumption, serum triglyceride and low-density lipoprotein (LDL) level were signi�cantly reduced and more than half of all patients � CRP levels decreased every month as well as the mean CRP level but no statistically signi�cant difference was found. e average erythrocyte glutathione peroxidase activity of patients was increased but not at signi�cant level; however, the mean serum 8-isoprostane level was signi�cantly lower aer mulberry treatment for 12 weeks. It can be concluded that mulberry leaf powder exhibited antioxidant activity and mulberry leaf powder has potential to decrease serum triglyceride, LDL, and CRP levels in mild dyslipidemia patients without causing severe adverse reactions. 1. Introduction Mulberries (Morus alba L., Moraceae) have been widely used in traditional Oriental medicine for several applications including prevention of diabetes [1]. It contains various nutritional components such as �avonoids and polyphenols, especially 1-deoxynojirimycin (DNJ), a potent glucosidase inhibitor, which shows hypoglycemic [2], hypolipidemic [3], and antiatherogenic effects [4, 5] in certain animal models. Shibata et al. [6] reported that mulberry leaf-derived aqueous fractions inhibit tumor necrosis factor--induced nuclear factor B activation and lectin-like oxidized low-density lipoprotein receptor-1 expression in vascular endothelial cells. Harauma et al. [5] also found that mulberry leaf powder can prevent atherosclerosis in apolipoprotein E-de�cient mice. Our earlier research also found that mulberry leaf powder was effective in reducing lipid pro�le in mild hyper- lipidemia patients [3]. Even though mulberry leaf powder seems to have several advantages in cardiovascular diseases, very few studies have been investigated in human subjects. Dyslipidemia with high serum cholesterol, both total cholesterol and low-density lipoprotein (LDL), and low high- density lipoprotein (HDL), is a critical cardiovascular risk factor [7, 8]. It is now established that oxidation of LDL constitutes a key event in in�ammation and atherogenesis [9]. Mechanisms of LDL oxidation involve concerted mod- i�cation by oxidants produced by arterial wall cells, such as reactive nitrogen species, hydroxyl radicals, and lipid-soluble free radicals [10]. Because most mechanisms involve the oxidation process, antioxidants may be useful in preventing endothelium blood vessel related to atherosclerosis. ere is extensive evidence that link hypercholestero- lemia with increased lipid peroxidation and increased oxida- tive stress [11, 12]. e oxidative modi�cation of lipoproteins, particularly LDL, has emerged as a fundamental process