This is the author manuscript accepted for publication and has undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1002/JPER.18-0568. This article is protected by copyright. All rights reserved. Effect of Maternal Periodontitis on GLUT4 and Inflammatory Pathway in Adult Offspring Maria Sara de Lima Coutinho Mattera * , MSc; Fernando Yamamoto Chiba † , Ph.D.; Flávia Lombardi Lopes ‡ , Ph.D.; Thaís Verônica Saori Tsosura * , MSc; Maria Angelica Peres § , Ph.D.; Victor Gustavo Balera Brito * , MSc; Sandra Helena Penha de Oliveira * , Ph.D.; Renato Felipe Pereira * , MSc; Fernando Marani * , MSc; Rodrigo Martins dos Santos * , MSc; Bianca Elvira Belardi * , Undergraduate student; Gestter Willian Lattari Tessarin ‖ , MSc; Mariana Lopes Benites * , Ph.D.; Edilson Ervolino ‖ , PhD; Joel Claudio Heimann § , Ph.D.; Doris Hissako Sumida * , Ph.D * Multicenter Post-Graduate Program in Physiological Sciences (SBFis), Department of Basic Sciences, São Paulo State University (Unesp), School of Dentistry, Araçatuba, Brazil † Department of Child and Social Dentistry, São Paulo State University (UNESP), School of Dentistry, Araçatuba, Brazil ‡ São Paulo State University (UNESP), School of Veterinary Medicine, Araçatuba, Brazil § Department of Internal Medicine, Laboratory of Experimental Hypertension of the University of São Paulo School of Medicine, São Paulo, Brazil ‖ São Paulo State University (Unesp), Institute of Biosciences, Botucatu, Brazil and Department of Basic Sciences, Division of Histology, Dental School of Aracatuba, UNESP-Univ Estadual Paulista, Araçatuba, Brazil Correspondence: Maria Sara de Lima Coutinho Mattera São Paulo State University (UNESP), School of Dentistry Araçatuba, Brazil - R. José Bonifácio, 1193, ZIP CODE: 16015-050, Araçatuba-SP, Brazil Tel: (+55) 18 3636 2819; Fax: (+55) 18 3636 3233; E-mail:mariasara_lc@hotmail.com The authors report no conflicts of interest related to this study. Word count: 3746; Number of figures: 3; Number of tables: 3; References: 48 Short running title: Maternal periodontitis, inflammatory pathways and GLUT4 Summary: Maternal periodontal disease causes activation of inflammatory pathways, and decreased GLUT4 expression in the gastrocnemius muscle of adult offspring.