Accepted Manuscript Synthesis of a novel legumain-cleavable colchicine prodrug with cell-specific toxicity Robert Løvsletten Smith, Ove Alexander Høgmoen Åstrand, Luan Minh Nguyen, Tina Elvestrand, Gunnar Hagelin, Rigmor Solberg, Harald Thidemann Johansen, Pål Rongved PII: S0968-0896(14)00330-7 DOI: http://dx.doi.org/10.1016/j.bmc.2014.04.056 Reference: BMC 11551 To appear in: Bioorganic & Medicinal Chemistry Received Date: 7 January 2014 Revised Date: 14 March 2014 Accepted Date: 28 April 2014 Please cite this article as: Smith, R.L., Åstrand, O.A.H., Nguyen, L.M., Elvestrand, T., Hagelin, G., Solberg, R., Johansen, H.T., Rongved, P., Synthesis of a novel legumain-cleavable colchicine prodrug with cell-specific toxicity, Bioorganic & Medicinal Chemistry (2014), doi: http://dx.doi.org/10.1016/j.bmc.2014.04.056 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.