Correspondence*: Muhammad Ikhsan Mokoagow, Division of Endocrinology, Metabolism, and Diabetes, Department of Internal Medicine, Fatmawati General Hospital, West Cilandak, South Jakarta, 12430, Indonesia, E-mail: mimokoagow@gmail.com, Phone: +62 815 8414 9555 Mokoagow, et al. Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal). 2022; 17 (4): 257-263 DOI: 10.21109/kesmas.v17i4.6301 Abstract Diabetes mellitus is a metabolic disorder characterized by chronic hyperglycemia that can cause various complications, economic burdens, and psychosocial issues that eventually lead to depression. This study aimed to describe the prevalence of depression among type 2 diabetes mellitus patients in the Internal Medicine Outpatient Clinic of a South Jakarta tertiary hospital during the COVID-19 pandemic. This cross-sectional study was conducted from May to July 2021. The data were collected consecutively from 100 patients aged 18 years or older who came for regular consultation. The instrument used for determining depression is Beck Depression Inventory-II. The prevalence of depression, a correlation between depression and participant’s characteristics, and multivariate analysis for risk factors were determined. The results showed that the prevalence of mild to severe depression based on the BDI-II classification was 17%. Screening showed mild to severe depression predominantly in females above 60 years old, with higher levels of education, obesity grade I, individuals with one or more comorbidities, and those who had diabetes for more than ten years. In this study, having one or more comorbidities was associated with an in- creased risk of depression in people with diabetes. Keywords: Beck Depression Inventory-II, depression screening, diabetes mellitus, prevalence of depression Factors Associated with Depression among Type 2 Diabetes Mellitus Patients at a Tertiary Hospital during the COVID-19 Pandemic Muhammad Ikhsan Mokoagow 1,2 *, Dian Pitawati 3 , Ditya Nona Arisandy 4 , Nadya Magfira 2 , Pratiwi Indah Palupi 2 , Jerry Nasarudin 1,2 , Marina Epriliawati 1,2 , Ida Ayu Kshanti 1,2 1 Division of Endocrinology, Metabolism, and Diabetes, Department of Internal Medicine, Fatmawati General Hospital, Jakarta, Indonesia, 2 Diabetes Integrated Care Center, Fatmawati General Hospital, Jakarta, Indonesia, 3 Department of Psychiatry, Fatmawati General Hospital, Jakarta, Indonesia, 4 Department of Research and Development, Fatmawati General Hospital, Jakarta, Indonesia Introduction Noncommunicable Diseases (NCDs) are by far the leading causes of death globally. According to global trends, the World Health Organization (WHO), stated that NCDs contributed to 71% (41 million) of 57 million deaths that occurred globally in 2016. 1 NCDs include cardiovascular disease, cancer, chronic respiratory dis- ease, and diabetes. Based on WHO data in 2020, Indonesia, with an estimated population of 261,100,000, has a 1,365,000 total death rate caused by NCDs or ap- proximately 73%, with diabetes as one of the etiologies. 2 In 2019, according to International Diabetes Federation (IDF), 463 million adults aged 20–79 years old worldwide had diabetes, with about 79.4% sufferers living in low and middle-income countries. Of that 463 million adults, 240.1 million (9.6%) are male, and 222.9 million (9.0%) are female. In 2019, IDF estimated that there would be 578.4 million diabetes patients in 2030. The total number will increase to 700.2 million in 2045. 3 The 2018 National Basic Health Research/ Riset Kesehatan Dasar (Riskesdas) documented diabetes prevalence based on doctor’s diagnosis in the population older than 15 years old is 2%. The highest prevalence of diabetes mellitus (DM) based on a doctor’s diagnosis and more than 15 years old is in Jakarta, with a total percent- age of 3.4%. 4 Diabetes creates economic and health burdens and poses various psychosocial issues to people with diabetes (PWD), such as depression. 1,3,5 As the most common mental disorder, depression commonly affects PWD. It has a bidirectional relationship: diabetes increases the risk of future depression, and depression increases the risk of having diabetes. 5 Patients with diabetes need a comprehensive self-management plan (monitoring blood glucose, daily oral antidiabetic drugs and/or insulin in- jection, and committing to a healthy lifestyle, including a nutritional diet and physical activity). 3 Because of those things, they may have difficulties of accepting and ad- justing a comprehensive self-management plan to differ- ent levels, which will pose a practical and psychological burden. In addition to psychological mechanisms, bio- logical mechanisms, such as inflammation, may have a role in the relationship between depression and dia- betes. 5 Received : October 21, 2022 Accepted : November 26, 2022 Published : November 30, 2022 Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal) Copyright @ 2022, Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal), p-ISSN: 1907-7505, e-ISSN: 2460-0601, SINTA-S1 accredited, http://journal.fkm.ui.ac.id/kesmas, Licensed under Creative Commons Attribution-ShareAlike 4.0 International