Research Article Open Access Journal of Surgery [Jurnalul de Chirurgie] J o u r n a l o f S u r g e r y [ J u r n a l u l d e C h i r u r g i e ] ISSN: 1584-9341 Volume 13 • Issue 2 • 3 J Surgery, an open access journal ISSN: 1584-9341 Keywords: Pancreatic cancer; Pancreatectomy; Survival Introduction Pancreatic cancer is one of the most lethal malignancies worldwide, and ranks fourth in the total number of deaths related to cancer in patients of both genders. Moreover, in 2013 the United States registered about 45,000 new cases, and reported that the number of expected deaths was very similar to the number of new cases. Also, the median overall survival at 5 years is between 2 and 6% [1]. Also, adenocarcinoma of the pancreas is the most common type of pancreatic neoplasm, with all of its subtypes accounting for 85% of cases [1,2]. Currently, curative treatment is only possible in cases of resectable disease and during the initial stages [3]. Still, although complete surgical resection is the only potential curative approach of this disease, it can only be performed in 10 to 20% of patients, since most individuals present with advanced disease upon diagnosis [3,4]. Moreover, afer surgical resection, 7 to 25% of patients have a 5-year survival rate [5], with better results in individuals which undergo curative resection (R0) [6]. Te prognosis for the patients with pancreatic cancer and which have indication for the resection with curative intent is determined by the lymphatic metastasis, the invasion of vascular walls and the peripancreatic nerve plexus or also by the degree of the micrometastases in nearby tissues and organs. As we mentioned before, unfortunately 95% of patients come to the doctor when the cancer is advanced and unresectable [7-9]. Moreover, in the recent decades the development of surgical techniques have only improved postoperative mortality, without having any signifcant impact on the survival, with specialized pancreatic surgery centres reporting a mortality below 5% [10,11]. Approximately 60% of pancreatic cancers have cephalic location. With the reduction of operative mortality afer duodenopancreatectomies, improved survival rates of 30% were reported [12], which is three times higher than previously published results [13,14]. *Corresponding author: Mihaela Blaj, MD, PhD, Department of Anesthesiology, Grigore T Popa University of Medicine and Pharmacy, “St Spiridon” Hospital, Bd. Independentei No 1, Iasi, Romania, Tel : + 40 (0) 232 24 08 22; E-mail: miblaj@yahoo.com Received December 15, 2016; Accepted January 13, 2017; Published January 20, 2017 Citation: Timofte D, Blaj M, Petrariu F, Ionescu L, Ochiuz L. Survival Prediction for Romanian Patients with Pancreatic Cancer. Journal of Surgery [Jurnalul de chirurgie]. 2017; 13(2): 59-61 DOI: 10.7438/1584-9341-13-2-3 Copyright: © 2017 Timofte D, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Abstract Pancreatic cancer is one of the most lethal malignancies worldwide and in some of the latest statistics ranks fourth in the total number of deaths related to cancer in patients of both genders. Currently, curative treatment is only possible in cases of resectable disease and during the initial stages. Still, although complete surgical resection is the only potential curative approach of this disease, it can only be performed in 10 to 20% of patients, since most individuals present with advanced disease upon diagnosis. Moreover, in the recent decades the development and improvement of surgical techniques have only improved postoperative mortality, without having any signifcant impact on the survival, with specialized pancreatic surgery centres reporting mortality below 5%. In this way, in the present study conducted on 188 patients from the “St. Spiridon” Clinical Emergency Hospital Iasi, we were interested in determining the survival rates in pancreatic cancer, as well as looking at the staging criteria for adenocarcinoma of the pancreas that follows the tumor/node/metastasis (TNM) system and the correlations between any of these stages and the overall survival. Weibull distribution was used to estimate the overall survival. Reduced survival in pancreatic cancer was found to be within the limits found in the published literature: 41.7% at 1 year, 8.7% at 3 years and 1.9% at 5 years. Still, no signifcant correlation was found between any of the disease stages and the overall survival. Survival Prediction for Romanian Patients with Pancreatic Cancer Daniel Timofte 1 , Mihaela Blaj 2 *, Florin Petrariu 3 , Lidia Ionescu 1 and Lăcrămioara Ochiuz 1 1 Department of Surgery, Grigore T Popa University of Medicine and Pharmacy, Iasi, Romania 2 Department of Anesthesiology, Grigore T Popa University of Medicine and Pharmacy, Iasi, Romania 3 Department of Pathology, Grigore T Popa University of Medicine and Pharmacy, Iasi, Romania However, early results improvement (decreased mortality, increase resectability rate) and the long-term survival are diferent aspects and it seems that sometimes there is no causal relationship between them. Moreover, some surgeons are not fully confdent in these sudden improvements of the survival parameters, as it was suggested by several authors, an increase need for the anatomopathological reconfrmation of the original diagnosis, while other authors have proposed standardized methods of evaluation and reporting systems of survival data and a clear delimitation for the subgroups of patients [15]. For now, surgical resection is still the best chance to prolong the disease-free interval. In addition, with all the development in perioperative management and despite the reduction in operative mortality corresponding to more aggressive resections, the literature showed no appreciable improvement for this disease over the past 20 years [16]. In this way, in the present study conducted on 188 patients from the local Clinical Emergency Hospital “Sf. Spiridon” Iasi, Romania, we were interested in determining the survival rates in pancreatic cancer, as well as looking at the staging criteria for adenocarcinoma of the pancreas that follows the tumor/node/metastasis (TNM) system and the correlations between any of these stages and the overall survival. Materials and Methods Tis study was conducted on 188 patients from Clinical Emergency Hospital “Sf. Spiridon” Iasi, Romania, all with solid form of pancreatic