1 Glycogen-Nucleic Acid Constructs for Gene Silencing in Multicellular Tumor Spheroids Marcin Wojnilowicz 1 , Quinn A. Besford 1 , Yun-Long Wu 2 , Xian Jun Loh 3,4 , Julia A. Braunger 1 , Agata Glab 1 , Christina Cortez-Jugo 1 , Frank Caruso* 1 and Francesca Cavalieri* 1,5 1 ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, and the Department of Chemical Engineering, The University of Melbourne, Parkville, Victoria 3010, Australia 2 Fujian Provincial Key Laboratory of Innovative Drug Target Research and State Key Laboratory of Cellular Stress Biology, School of Pharmaceutical Sciences, Xiamen University, Xiamen, P. R. China 3 Institute of Materials Research and Engineering, A*STAR (Agency for Science, Technology and Research), 2 Fusionopolis Way, Innovis, #08-03, Singapore 138634, Singapore 4 Department of Materials Science and Engineering, National University of Singapore, 9 Engineering Drive 1, Singapore 117576, Singapore 5 Dipartimento di Scienze e Tecnologie Chimiche, Universita’ degli Studi di Roma “Tor Vergata”, via della ricerca scientifica 1, 00133 Rome, Italy *Corresponding authors: E-Mail: francesca.cavalieri@unimelb.edu.au. E-Mail: fcaruso@unimelb.edu.au.