In a door-to-door survey in Rabat–Casablanca regions, in Morocco, involving a total of 60,031 individuals (36,756 urban and 3275 rural), investigators identify through the use a specific questionnaire a possible stroke patient and also households where one person died of a possible stroke. In a second step neurologists confirmed the stroke in survivors and stroke death by using a specific verbal autopsy. We identified 51 first-ever stroke during one year. The incidence rate standardized to Segi's world population was 97.9 per 100,000 (95% CI 73–123) and the incidence rate in people aged over 55 years was 550.6 per 100,000 (95% CI 381–721) with 467.4 (95% CI 269–666) in urban and 691.4 (95% CI 381–1002) in rural. Our results show that incidence rate of stroke is significantly high in people aged over 55 years specially in rural area, which are similar to those reported in community studies both in developed countries (Feigin et al., 2003) or in emerging countries (Lavados et al., 2005). We believe that the use of specific verbal autopsy in door-to-door survey of stroke provides good approximation of stroke incidence in developing countries. doi:10.1016/j.jns.2013.07.771 Abstract — WCN 2013 No: 1137 Topic: 3 — Stroke Serial hemodynamic and autonomic function studies in acute ischemic stroke: Relation to outcome, stroke type and location A. Gujjar a , D. Jaju b , P.C. Jacob c , M. Dixit b , A.R. Al-Asmi c . a Medicine (Neurology), College of Medicine, Sultan Qaboos University, Al Khod, Oman; b Physiology, Sultan Qaboos University, Muscat, Oman; c Medicine (Neurology), Sultan Qaboos University, Muscat, Oman Background: Hypertension and autonomic changes commonly accompany acute ischemic stroke (AIS); however, their pathophys- iology is poorly understood. Aim: To study serial hemodynamic and cardiovascular autonomic functions among patients with AIS and to explore their relation to stroke outcome, location, type and severity. Patients and methods: Patients with AIS of b 96 h duration underwent serial hemodynamic and cardiovascular autonomic function studies using thoracic electrical bioimpedance technology over the first 4 days of admission. Patients with arrhythmias or pulmonary edema were excluded. Correlations between NIHSS scores, outcome at follow-up (mean 10 months), stroke type, location and hemodynamic/autonomic parameters were explored using Mann–Whitney U-test and logistic regression analysis. Results: 55 patients (M:F:27:28; age:62 ± 12 years) with AIS were studied. 33 had large artery stroke, 18—lacunar and 4—cardioembolic. 6 patients (11%) died. Mean BP decreased by 8 mm Hg by day 4 (D4); while cardiac output remained stable, systemic vascular resistance (SVR) changes reciprocated BP. Lower NIHSS at admission, SVR (D2), systolic BP (D4), and cardiac index (CI, D1) correlated significantly (p b 0.01) with good outcome, as did following autonomic indices: sympathetic activity (LFNU; LFNuBPV); parasympathetic activity (HFNU); sympathovagal balance (Lf/HF); barareflex sensitivity (BRS) and ventric- ular work (LVWI). Systolic BP (D4) predicted outcome independently. Stroke location in the basal-ganglia was related to left ventricular ejection time and sympathovagal balance (LF/HF) (p b 0.05). Conclusion: Hypertension in AIS may be mediated predominantly by changes in SVR. Hemodynamic and autonomic parameters may predict outcome and possibly stroke location. Further studies among patients with homogenous stroke types may help understand the interaction between focal brain injury and autonomic changes. doi:10.1016/j.jns.2013.07.772 Abstract — WCN 2013 No: 1336 Topic: 3 — Stroke Thrombolysis in acute ischaemic stroke: Initial experience in a general hospital in a developing country I. Milojević, I. Milenković, S. Krstić. Department of Neurology, General Hospital Ćuprija, Cuprija, Serbia Background: The aim of the study was to present our initial experience with the use of intravenous thrombolytic therapy in patients with acute ischaemic stroke. We present results related to demography, time, and data on the clinical outcome of patients and compare the results with other studies (Serbian Experience with Thrombolysis in Ischemic Stroke (SETIS) and Safe Implementation of Treatments in Stroke (SITS)). Objective: Define risk factors in our community, characteristics of clinical course and outcome in patient with acute ischemic stroke proven neuroradiologicaly (CT) after IV application rt-PA (0.9 mg/kg). Patients and methods: Study involved 15 patients treated with rt- PA in our hospital between the years 2011–2013. Results: The research included 15 patients (F:M = 4:11), median age 65 (53–77). The most frequent risk factors were: hypertension 86.6%, atrial fibrillation (AF) 40%, diabetes mellitus 33.3%, hyperlipidemia 53.3%, and smoking 26.6% , 6.6% had no risk factors. Ischemic lesion proven CT in 8 patients was on left side hemisphere 8/15 (53.3%), right side hemisphere 5/15 (33.3%), cerebellum 1/15 (6.6%) and brainstem 1/15 (6.6%). Due the hospitalization the improvements were registered in 11/15 (73.3%), unchanged at 3/15 (20%) and one lethal result. Initial NIHSS score was 8.45 (4–17), modified Rankin scale (mRS) after 3 month 0–2 (1.53), and onset-to-needle time was 168.5 (125–250) min. Conclusion: Of course, we are aware that a good outcome (above the average monitoring studies) is the result of an engaged approach. We want to show the results in order to encourage colleagues working in hospitals of similar size and equipment in countries with similar social, demographic and economic characteristics. doi:10.1016/j.jns.2013.07.773 Abstract — WCN 2013 No: 1312 Topic: 3 — Stroke Systemic allostatic overload in acute stroke P.F. Fiori a , A. Morella b , G. Bellizzi b , V. Pellecchia b , L. Iurato a , G. Esposito c , C. Tammaro c , E. Mazza d , M. Rossi d , L.M. Giannetti e , M. D'Avanzo f , M. Raffa g , E. Pace g , V.M.N. Ferrante h , A. Monaco a . a Neurology, S. Ottone Frangipane ex Civil Hospital — II University of Naples, Ariano Irpino, AV, Italy; b Cardiology, S. Ottone Frangipane ex Civil Hospital — II University of Naples, Ariano Irpino, AV, Italy; c Laboratory, S. Ottone Frangipane ex Civil Hospital — II University of Naples, Ariano Irpino, AV, Italy; d Radiology, S. Ottone Frangipane ex Civil Hospital — II University of Naples, Ariano Irpino, AV, Italy; e Infantile Neuropsychiatry — Social Service, S. Ottone Frangipane ex Civil Hospital — II University of Naples, Ariano Irpino, AV, Italy; f First Aid, S. Ottone Frangipane ex Civil Hospital — II University of Naples, Ariano Irpino, AV, Italy; g Intensive Care — Anesthesiology, S. Ottone Frangipane ex Civil Hospital — II University of Naples, Ariano Irpino, AV, Italy; h Didactic Pole, S. Ottone Frangipane ex Civil Hospital — II University of Naples, Ariano Irpino, AV, Italy The aim of our study is to characterise cerebrovascular patients concerning cardiovascular functions. Haematological analyses were performed within 24–48 h on 476 Acute Stroke (AS), 1142 Chronic Cerebro-Vascular Disease (CCVD) and 216 Other Neurological Disease (OND) patients, among which 161 AS, 504 CCVD, 83 OND underwent echocardiography. Abstracts / Journal of the Neurological Sciences 333 (2013) e152–e214 e191