TYPE Review PUBLISHED 15 September 2022 DOI 10.3389/fmed.2022.903739 OPEN ACCESS EDITED BY Alicia Mohr, University of Florida, United States REVIEWED BY Bálint Mihály Eross, University of Pécs, Hungary Sinem Civriz Bozda˘ g, Ankara University, Turkey *CORRESPONDENCE Miguel Montoro maimontoro@gmail.com † These authors have contributed equally to this work SPECIALTY SECTION This article was submitted to Gastroenterology, a section of the journal Frontiers in Medicine RECEIVED 24 March 2022 ACCEPTED 11 August 2022 PUBLISHED 15 September 2022 CITATION Montoro M, Cucala M, Lanas Á, Villanueva C, Hervás AJ, Alcedo J, Gisbert JP, Aisa ÁP, Bujanda L, Calvet X, Mearin F, Murcia Ó, Canelles P, García López S, Martín de Argila C, Planella M, Quintana M, Jericó C and García Erce JA (2022) Indications and hemoglobin thresholds for red blood cell transfusion and iron replacement in adults with gastrointestinal bleeding: An algorithm proposed by gastroenterologists and patient blood management experts. Front. Med. 9:903739. doi: 10.3389/fmed.2022.903739 COPYRIGHT © 2022 Montoro, Cucala, Lanas, Villanueva, Hervás, Alcedo, Gisbert, Aisa, Bujanda, Calvet, Mearin, Murcia, Canelles, García López, Martín de Argila, Planella, Quintana, Jericó and García Erce. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Indications and hemoglobin thresholds for red blood cell transfusion and iron replacement in adults with gastrointestinal bleeding: An algorithm proposed by gastroenterologists and patient blood management experts Miguel Montoro 1,2,3,4 * † , Mercedes Cucala 5 , Ángel Lanas 2,4,6,7 , Cándido Villanueva 7,8 , Antonio José Hervás 9 , Javier Alcedo 2,10 , Javier P. Gisbert 7,11,12 , Ángeles P. Aisa 13 , Luis Bujanda 7,14,15 , Xavier Calvet 7,16,17 , Fermín Mearin 18 , Óscar Murcia 19 , Pilar Canelles 20 , Santiago García López 2,10 , Carlos Martín de Argila 21 , Montserrat Planella 22,23 , Manuel Quintana 24,25 , Carlos Jericó 26,27 , and José Antonio García Erce 25,27,28,29† on behalf of the Spanish Association of Gastroenterology (AEG) 1 Unidad de Gastroenterología, Hepatología y Nutrición, Hospital Universitario San Jorge, Huesca, Spain, 2 Departamento de Medicina, Universidad de Zaragoza, Zaragoza, Spain, 3 Instituto Aragonés de Ciencias de la Salud (IACS), Zaragoza, Spain, 4 Instituto de Investigación Sanitaria Aragón (IIS), Zaragoza, Spain, 5 Vifor Pharma, Barcelona, Spain, 6 Servicio de Aparato Digestivo, Hospital Clínico Universitario “Lozano Blesa”, Zaragoza, Spain, 7 Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Madrid, Spain, 8 Servei de Digestiu, Hospital de la Santa Creu y Sant Pau, Universidad Autónoma de Barcelona, Barcelona, Spain, 9 Unidad de Gestión Clínica de Aparato Digestivo, Hospital Universitario Reina Sofía de Córdoba, Córdoba, Spain, 10 Servicio de Aparato Digestivo, Hospital Universitario Miguel Servet, Zaragoza, Spain, 11 Servicio de Aparato Digestivo, Hospital Universitario de La Princesa, Madrid, Spain, 12 Instituto de Investigación Sanitaria Princesa (IIS-IP), Universidad Autónoma de Madrid (UAM), Madrid, Spain, 13 Servicio de Aparato Digestivo, Hospital Universitario Costa del Sol, Marbella, Spain, 14 Servicio de Aparato Digestivo, Hospital Universitario Donostia, Donostia, Spain, 15 Instituto de Investigación Sanitaria Biodonostia, Universidad del País Vasco (UPV/EHU), Donostia, Spain, 16 Servei de Digestiu, Corporació Sanitaria Park Taulí, Sabadell, Spain, 17 Department of Medicine, Universidad Autónoma de Barcelona, Barcelona, Spain, 18 Servicio de Aparato Digestivo, Centro Médico Teknon, Barcelona, Spain, 19 Servicio de Aparato Digestivo, Hospital General Universitario de Alicante, Alicante, Spain, 20 Servicio de Aparato Digestivo, Hospital General Universitario de Valencia, Valencia, Spain, 21 Servicio de Aparato Digestivo, Hospital Universitario Ramón y Cajal, Madrid, Spain, 22 Servei de Digestiu, Hospital Universitario Arnau de Vilanova, Lleida, Spain, 23 Department of Medicine, Universidad de Lleida, Lleida, Spain, 24 Servicio a Medicina Intensiva, Hospital Universitario La Paz (IdiPAZ), Madrid, Spain, 25 PBM Group, Hospital La Paz Institute for Health Research (IdiPAZ), Madrid, Spain, 26 Servicio de Medicina Interna, Complex Hospitalari Moisès Broggi, Sant Joan Despí, Barcelona, Spain, 27 Grupo Español de Rehabilitación Multimodal (GERM), Zaragoza, Spain, 28 Banco Frontiers in Medicine 01 frontiersin.org