Professional Med J 2017;24(5):650-655. www.theprofesional.com HbA1c AND LIPID PROFILE 650 The Professional Medical Journal www.theprofesional.com HbA1c AND LIPID PROFILE; CORRELATION WITH THE COMPLEXITY OF CORONARY ARTERY DISEASE Dr. Faraz Farooq Memon 1 , Dr. Nandlal Rathi 2 , Dr. Qurban Ali Rahoo 3 , Dr. Bhunesh Maheshwari 4 , Dr. Mariya Maheshwari 5 , Dr. Feroz Memon 6 ORIGINAL PROF-3753 ABSTRACT… Objectives: The aim behind this study was to scientifcally correlate the glycosylated hemoglobin and lipid profle with the complexity of coronary artery disease. Study Design: Comparative hospital based study. Setting: Cardiology Department of Isra University Hospital Hyderabad. Period: Six months. Patients and Methods: 112 participants between the ages of 25 to 80 years both male and female and undergoing their frst coronary angiography was included. Data were entered and analyzed by using Statistical Package for the Social Sciences version 20.0. Results: The mean age of patients was 54.16 years (9.74 ± SD) and the study subjects consisted of 76 males (67.86%) and 36 (32.14%) females. a total of 65 patients (58.0%) were presented between the ages of 41 – 60 years (middle aged group). The mean SYNTAX Score was 15.22. Patients with increased HbA1C (≥6.5%) and triglyceride levels (≥150 mg/dl) and decreased HDL-C levels (≤40 mg/dl) were tend to have high Sx score. However, we did not fnd any signifcant relationship of SX score with total cholesterol and LDL-C levels. Conclusion: It was found that the trend of complexity of CAD increased with increasing age, high HbA1C, high LDL-C, high serum triglyceride, and low HDL-C levels. Key words: SYNTAX Score, coronary artery disease complexity, HbA1C. 1. PG Student Department of Cardiology Isra University Hospital, Hyderabad. 2. Associate Professor, Department of Cardiology Isra University Hospital, Hyderabad. 3. Associate Professor Department of Cardiology Peoples Medical University Shaheed Benazirabad. 4. Medical Offcer Indus Medical College Tando Muhammad Khan. 5. Medical Offcer Indus Medical College Tando Muhammad Khan. 6. Professor, Department of Cardiology Isra University Hospital, Hyderabad. Correspondence Address: Dr. Faraz Farooq Memon PG Student Department of Cardiology Isra University Hospital, Hyderabad. farazkashif@yahoo.com Article received on: 02/12/2016 Accepted for publication: 25/03/2017 Received after proof reading: 06/05/2017 Article Citation: Memon FF, Rathi N, Rahoo QA, Maheshwari B, Maheshwari M, Memon F. HbA1c and lipid profle; correlation with the complexity of coronary artery disease. Professional Med J 2017;24(5):650-655. DOI: 10.17957/TPMJ/17.3753 INTRODUCTION Diabetes mellitus is a chronic long standing disease which has a signifcant role in the development and worsening of coronary artery disease other than the most common systemic involvements. Abnormally raised in the blood sugar levels persistently may increase the incidence of coronary artery disease (CAD) in otherwise healthy population. Previously published data suggest that atherosclerosis, formation and deposition of lipids in vessels, is enhanced after the patients diagnosed with diabetes mellitus and if not properly controlled may lead to its chronic disabilitating complications such as myocardial infarction and stroke. 1 Mortality due to CAD in North America and Western Europe in the last decades has effectively reduced by a good health care system. 2,3 But, it has expanded in the Asia mainly due to lack of awareness, unhealthy life style and poor health care system. 4 Diabetes and Dyslipidemia has been major risk factors for the development of CAD around the world as well as in Pakistan. Most of the cardiovascular diseases are caused by the underlying presence of atherosclerotic changes which starts since adulthood and increase in the burden of atherosclerosis can be caused by some already known modifed and non-modifable risk factors in which diabetes mellitus has a major role. Proper recognition of these underlying risk factors is very useful in prevention and cardiovascular disease in both man and women. An angiographic based grading tool is designed with a name of SYNTAX score system to determine the complexity of coronary artery disease and to decide which patient gets beneft from CABG or PCI. One of a very famous SYNTAX trial which has been conducted recently has observed the outcome of patients with multivessel coronary artery disease along with involvement of left main DOI: 10.17957/TPMJ/17.3753