JPET #110965 1 Reactive Oxygen Species Mediate Caspase Activation and Apoptosis Induced by Lipoic Acid in Human Lung Epithelial Cancer Cells through Bcl-2 Downregulation Jirapan Moungjaroen, Ubonthip Nimmannit, Patrick S. Callery, Liying Wang, Neelam Azad, Vimolmas Lipipun, Pithi Chanvorachote, and Yon Rojanasakul Department of Pharmaceutical Sciences, West Virginia University, Morgantown, West Virginia, USA (J.M., P.S.C., N.A, Y.R.) Pharmaceutical Technology (International) Program (J.M., U.N., P.C.) and Department of Microbiology (V.L.), Chulalongkorn University, Bangkok, Thailand Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA (L.W.) JPET Fast Forward. Published on September 21, 2006 as DOI:10.1124/jpet.106.110965 Copyright 2006 by the American Society for Pharmacology and Experimental Therapeutics. This article has not been copyedited and formatted. The final version may differ from this version. JPET Fast Forward. Published on September 21, 2006 as DOI: 10.1124/jpet.106.110965 at ASPET Journals on December 10, 2021 jpet.aspetjournals.org Downloaded from