Original Article Relationship between serum levels of oxidative stress and metabolic syndrome components Maryam Abbasian a , Mehri Delvarianzadeh b , Hossein Ebrahimi c, *, Farideh Khosravi d , Pirasteh Nourozi a a School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran b School of Public Health, Shahroud University of Medical Sciences, Shahroud, Iran c Randomized Controlled Trial Research Center, Shahroud University of Medical Sciences, Shahroud, Iran d Environmental and Occupational Health Research Center, Shahroud University of Medical Sciences, Shahroud, Iran A R T I C L E I N F O Article history: Available online xxx Keywords: Oxidative stress Metabolic syndrome Metabolic syndrome components A B S T R A C T Aims: This study aimed to investigate the relationship between the total antioxidant capacity (TAC) and Malondialdehyde (MDA) with number of metabolic syndrome (Mets) components on the personnel working in Shahroud University of Medical Sciences. Methods: This cross-sectional study was conducted on 167 personnel aged 30–60 years old. ATP III criteria were used to diagnose patients with MetS. Oxidative stress indicators were measured. The data was analyzed via one-way ANOVA, and Pearson and Spearman correlation coefficients. Results: The result showed that TAC had a significant positive correlation with HDL and a significant negative correlation with abdominal obesity. In addition, there was a significant positive association between the level of MDA and age, BMI, abdominal obesity, diastolic blood pressure, triglycerides, and LDL; however, it had a negative significant correlation with HDL. Conclusions: The measurement of TAC and MDA biomarkers can increase the early diagnosis of patients at risk of developing Mets. © 2018 Diabetes India. Published by Elsevier Ltd. All rights reserved. 1. Introduction Metabolic syndrome (Mets) is consisted of a group of disorders including abdominal obesity, hypertension, dyslipidemia, and insulin resistance [1]. Adult Treatment Panel (ATP III) is one of the most common and reliable standard methods used for the clinical diagnosis of the syndrome [2]. In addition to the risk factors outlined by the ATP III criteria, several studies have reported the role of oxidative stress in the pathogenesis of metabolic disorders associated with this syndrome [3–5]. Oxidative stress is caused by the imbalance between free radicals (prooxidants) and antioxi- dant systems; it can play an important role in the pathophysiolo- gy of diabetes, cardiovascular diseases, and hypertension [6]. On the other hand, some of the Mets factors such as hyperglycemia and inflammation can lead to increased production of reactive oxygen species (ROS); the reactive oxygen species have toxic effects which lead to peroxidation of membrane lipids and produce malondialdehyde (MDA) [7]. To deal with the reduction of oxidative stress, several antioxidant defense systems are developed which act both via their enzymatic and non-enzymatic effects. Non-enzymatic antioxidant defense system includes molecules such as glutathione, beta-carotene, vitamin C, A, E, and enzymatic antioxidant defense system includes important intracellular antioxidant enzymes such as catalase (CAT), glutathione reductase (GR), glutathione peroxidase (GPx), and superoxide dismutase (SOD) [6]. The measurement of the total antioxidant capacity (TAC) is taken into consideration as a useful tool for diagnosis and medical treatment of diseases such as cardiovascular diseases and diabetes mellitus [8]. In addition, the TAC level is used as one of the biological markers for monitoring oxidative stress in humans [9]. Although several studies have been conducted on the relationship between oxidative stress and Mets [3,10,11], there are still limited information on the relationship between oxidative stress and components of the syndrome. As a result, this study was conducted on the personnel working in Shahroud University of Medical Sciences and aimed to investigate the relationship between the number of Mets components and the indicators of oxidative stress (TAC and MDA as the marker of lipid peroxidation). * Corresponding author. E-mail addresses: abbasian39@yahoo.com (M. Abbasian), delvarianzadeh_mehri@yahoo.com (M. Delvarianzadeh), ebrahimi@shmu.ac.ir (H. Ebrahimi), faridehkhosravi50@yahoo.com (F. Khosravi), pirasteh_norozi@yahoo.com (P. Nourozi). https://doi.org/10.1016/j.dsx.2018.03.015 1871-4021/© 2018 Diabetes India. Published by Elsevier Ltd. All rights reserved. Diabetes & Metabolic Syndrome: Clinical Research & Reviews xxx (2018) xxx–xxx G Model DSX 935 No. of Pages 4 Please cite this article in press as: M. Abbasian, et al., Relationship between serum levels of oxidative stress and metabolic syndrome components, Diab Met Syndr: Clin Res Rev (2018), https://doi.org/10.1016/j.dsx.2018.03.015 Contents lists available at ScienceDirect Diabetes & Metabolic Syndrome: Clinical Research & Reviews journal homepa ge: www.elsev ier.com/locate/dsx