·Original article· Prophylactic tamsulosin in cataract surgery under general anesthesia for preventing urinary retention: a randomized clinical trial Nooshin Bazzazi 1 , Habib Mousavi Bahar 2 , Housein Kimiaei Asadi 3 , Siamak Akbarzadeh 1 , Daniel Fadaei Fouladi 4 1 Eye Ward, Farshchian Educational and Medical Center, Hamadan University of Medical Sciences, Hamadan 6516748741, Iran 2 Department of Urology, Hamadan University of Medical Sciences, Hamadan 6517619651, Iran 3 Department of Anesthesiology, Hamadan University of Medical Sciences, Hamadan 6517619651, Iran 4 Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz 5165665811, Iran Correspondence to: Siamak Akbarzadeh. Farshchian Educational and Medical Center, Hamadan University of Medical Sciences, Hamadan 6516748741, Iran. Medicorelax3@ yahoo. com Received: 2013-09-18 Accepted: 2013-12-12 术前应用坦索辛对全麻白内障患者尿潴留的 预防作用 Nooshin Bazzazi 1 , Habib Mousavi Bahar 2 , Housein Kimiaei Asadi 3 , Siamak Akbarzadeh 1 , Daniel Fadaei Fouladi 4 ( 作者单位: 1 伊朗, 哈马丹 6516748741, 哈马丹医科大学, Farshchian 教育和医疗中心, 眼科病房; 2 伊朗, 哈马丹 6516748741, 哈马丹医科大学, 泌尿外科系; 3 伊朗, 哈马丹 6516748741, 哈马丹医科大学, 麻醉系; 4 伊朗, 大不里士 5165665811,大不里士医科大学,药物应用研究中心) 通讯作者:Siamak Akbarzadeh. Medicorelax3@ yahoo. com 摘要 目的:检测术前应用坦索罗辛对全麻白内障患者尿潴留的 预防作用。 方法:对 67 名男性患者行全麻白内障手术, 口服坦索罗 辛,每日 0. 4mg(32 例) 或安慰剂( 35 例)。 比较两组术后 尿潴留和软盘虹膜综合征发生率。 结果:两组患者年龄,坦索罗辛组:68. 16依8. 72 岁;安慰剂 组:71. 37依8. 60 岁,(P = 0. 38 )。 术后坦索罗辛组尿潴留 发生率较低(3. 1% vs48. 6% ,P<0. 001 ; Odds ratio = 29. 28 , 95% CI 3. 59 ~ 238. 79)。 安慰剂组中 1 例(2. 9% )发生软盘虹 膜综合征(P = 0. 52;Odds ratio = 1. 03, 95% CI 0. 97 ~ 1. 09)。 结论:全麻白内障手术前口服坦索罗辛可有效防止术后尿 潴留,而不增加软盘虹膜综合征发生的风险。 关键词:术后尿潴留;坦索罗辛;软盘虹膜综合征 引用:Bazzazi N, Mousavi Bahar H, Kimiaei Asadi H, Akbarzadeh S, Fouladi DF. 术前应用坦索罗辛对全麻白内障患者尿潴留的 预防作用. 国际眼科杂志 2014;14(1):1-3 Abstract 誗AIM: To examine the effect of prophylactic tamsulosin in male candidates of cataract surgery on general anesthesia in preventing urinary retention. 誗METHODS: In this double blind clinical trial, 67 male candidates of cataract surgery under general anesthesia randomly received oral tamsulosin ( 0. 4mg daily for one week prior to cataract surgery, n = 32 ), or placebo ( n = 35) . Rates of post - operative urinary retention and floppy iris syndrome were compared between the two groups. 誗 RESULTS: The two groups were matched for the patients蒺 age ( tamsulosin group: 68. 16 依 8. 72 years, placebo group: 71. 37 依 8. 60 years, P =0. 38 ) . Post - operative urinary retention occurred less frequently in tamsulosin receivers ( 3. 1% vs 48. 6% , P <0. 001, Odds ratio = 29. 28, 95% CI 3. 59 - 238. 79 ) . There was only one case ( 2. 9% ) with floppy iris syndrome in the control group ( P =0. 52, Odds ratio =1. 03 95% CI 0. 97-1. 09) . 誗CONCLUSION: Short - term prophylactic administration of oral tamsulosin before cataract surgery on general anesthesia is effective in preventing post - operative urinary retention without increasing the risk of floppy iris syndrome. 誗KEYWORDS: postoperative urinary retention; tamsulosin; floppy iris syndrome DOI:10. 3980 / j. issn. 1672-5123. 2014. 01. 01 Citation: Bazzazi N, Mousavi Bahar H, Kimiaei Asadi H, Akbarzadeh S, Fouladi DF. Prophylactic tamsulosin in cataract surgery under general anesthesia for preventing urinary retention: a randomized clinical trial. Guoji Yanke Zazhi ( Int Eye Sci ) 2013;14 (1):1-3 INTRODUCTION C ataract is a very common problem among the elderly [1,2] . Despite an increasing tendency to perform cataract surgery under local anesthesia, general anesthesia is inevitable in some cases. Urinary retention may complicate these cases, noting that many of such patients primarily suffer from prostatic hyperplasia and detrusor muscle weakness [3,4] . Although using bladder catheters can resolve this problem, it may be accompanied with other complications such as infection [5] . Instead, different drugs, such as 琢 1 adrenergic antagonists ( terazosin, doxazosin, alfuzosin ) and 5 琢- reductase inhibitors ( finasteride, dutasteride ) have been proposed to prevent postsurgical urinary retention [6] . 1 Int Eye Sci, Vol. 14, No. 1, Jan. 2014 www. ies. net. cn Tel:029鄄82245172 82210956 Email:IJO. 2000@163. com