Page 1/33 Genetic Deletion of cyclooxygenase-1 ameliorates neuroinｧammation and cognitive impairment in 5×FAD mice Jie Wang The Academy of Integrative Medicine, Shanghai University of Traditional Chinese Medicine Hong Ni The Academy of Integrative Medicine, Shanghai University of Traditional Chinese Medicine luyao Wei The Academy of Integrative Medicine, Shanghai University of Traditional Chinese Medicine Hanqing Ding The Academy of Integrative Medicine, Shanghai University of Traditional Chinese Medicine Zhongzhao Guo The Academy of Integrative Medicine, Shanghai University of Traditional Chinese Medicine Ying Yu Department of Pharmacology and Tianjin Key Laboratory of Inｧammatory Biology, Tianjin Medical University Jia Luo Department of Pathology, University of Iowa Carver College of Medicine Zun-Ji Ke (  kezunji@shutcm.edu.cn ) The Academy of Integrative Medicine, Shanghai University of Traditional Chinese Medicine Research Article Keywords: Alzheimer’s disease, Cyclooxygenase-1, Microglia, Neuroinｧammation, Prostaglandin E2. NLRP3 inｧammasome Posted Date: February 3rd, 2023 DOI: https://doi.org/10.21203/rs.3.rs-2522132/v1 License:   This work is licensed under a Creative Commons Attribution 4.0 International License. Read Full License