414 The Journal of Phytopharmacology 2022; 11(6):414-420 Online at: www.phytopharmajournal.com Review Article ISSN 2320-480X JPHYTO 2022; 11(6): 414-420 November- December Received: 03-10-2022 Accepted: 19-11-2022 Published: 20-12-2022 ©2022, All rights reserved doi: 10.31254/phyto.2022.11607 Acharya Balkrishna 1. University of Patanjali, Patanjali Yogpeeth, Haridwar-249405, Uttarakhand, India. 2. Patanjali Herbal Research Department, Patanjali Research Institute, Haridwar-249405, Uttarakhand, India Vidhi Dobhal Patanjali Herbal Research Department, Patanjali Research Institute, Haridwar- 249405, Uttarakhand, India Sonam Verma Patanjali Herbal Research Department, Patanjali Research Institute, Haridwar- 249405, Uttarakhand, India Deepika Srivastava Patanjali Herbal Research Department, Patanjali Research Institute, Haridwar- 249405, Uttarakhand, India Shalini Singh Patanjali Herbal Research Department, Patanjali Research Institute, Haridwar- 249405, Uttarakhand, India Vedpriya Arya 1. University of Patanjali, Patanjali Yogpeeth, Haridwar-249405, Uttarakhand, India. 2. Patanjali Herbal Research Department, Patanjali Research Institute, Haridwar-249405, Uttarakhand, India Correspondence: Vidhi Dobhal Patanjali Herbal Research Department, Patanjali Research Institute, Haridwar- 249405, Uttarakhand, India Email: vidhi.dobhal@patanjali.res.in, phrd.publications@patanjali.res.in Arctigenin: A Potential Component with Multifaceted Therapeutic Properties Acharya Balkrishna, Vidhi Dobhal, Sonam Verma, Deepika Srivastava, Shalini Singh, Vedpriya Arya ABSTRACT Medicinal plants are an excellent source of new therapeutic drugs because of their phytochemical constituents. Arctium lappa L. (common name-burdock) is a perennial medicinal herb commonly found in China, Japan, Korea traditionally used as promising health supplement. promising health supplement. Major active constituent of A. lappa L. seeds are arctigenin which exhibits pharmacological potential such as anti-inflammatory, anticancer, antimicrobial and hepatoprotective properties. The purpose of this study is to provide an up-to-date evaluation of the literature on the pharmacological activities of Arctigenin from Articum lappa L. Literature is collected from Google scholar, Science Direct, Research Gate, PubMed, Google, and SciFinder databases published between 2012 and 2021 (Jan). Keywords used to retrieve the data are pharmacological profile, arctigenin, and Arctium lappa L. The antioxidant, anti-inflammatory, anti-tumor, hepatoprotective, renoprotective, neuroprotective, and CNS depressant properties of arctigenin demonstrated its pharmacological significance among traditional science According to different research, arctigenin is effective in the treatment of a variety of chronic disorders, including cancer (stomach, lungs, liver, and colon) and inflammatory diseases (rashes, and other skin conditions.). Future experiments based on the mechanism pathway responsible for the protective role of arctigenin's will help the scientist to uncover its health benefits. Keywords: Arctium lappa, Arctigenin, Botanical description, Medicinal uses, Pharmacological profile. INTRODUCTION Herbal medicine, encompasses ancient medical systems such as Ayurveda, Chinese herbal medicine, and Kampo [1] , which uses different plant parts and their extracts or fractions for therapeutic benefits [2] . Herbal medicine is well-known for its potential role as a complementary treatment for a variety of ailments. Traditional methods have also grown in popularity and recognition in recent years in terms of socioeconomic standing. These extracts have a range of action mechanisms [1] . Stir-heating, charring, steaming, boiling, and calcining are examples of traditional Chinese medicine treatments, dispensing, and preparations that have been used to improve the effectiveness and/or minimise the toxicity of crude medicines. It is commonly used to get rid of 'wind-heat,' ease sore throat inflammation and swelling, and detoxify the body [3] . With 1600 genera and over 23000 species worldwide, the Asteraceae family is one of the largest flowering plant families [4] . The genus Arctium L., popularly known as "burdock," is a group of biennial herbs that can be found along roadsides, streams, and waste sites, as well as in forests in temperate Europe and Asia and in subtropical and tropical locations. Arctium species contain nonvolatile compounds such as acetylenic compounds, lignans, phytosterols, fatty acids, polysaccharides, flavonoids, caffeoylquinic acid derivatives, terpenes/terpenoids, and volatile compounds such as carboxylic and fatty acids, hydrocarbons, aldehydes, methoxypyrazines, sesquiterpenes and monoterpenes. The Arctium genus possessed pharmacological properties including gastroprotective, hepatoprotective, anti-allergic, anti-cancer, anti-diabetic, antimicrobial, anti-oxidant, antiviral, and anti- inflammatory effects [5] . Plant morphology- Arctium lappa (burdock) L., also known as "niupang" in Chinese and "gobo" in Japanese [6] . It is a European and Asian native that is increasingly spreading through North America [7] . Burdock is an herbaceous biennial plant with pubescent to subglabrous epigeal portions that grows up to 150 cm tall. The basal leaves are oval, cordate, and hollow petioles with a diameter of 50 cm. The stems are branching and have corymbose capitula at the end. Florets are the same length as the involucral bracts. The roots are slender (about 0.71 m long and 0.20.3 m across), very crisp, and have a sweet, mild, and pungent flavour [5] .