CT Imaging of Orbital Lymphoma with Pathological Correlation: Case Series A.T. Basja a , L. Mardiyana b* , S. Fatmariyanti c , N. Kurniasari d , S. Amanda e *Corresponding author, email: lies.mardiyana@fk.unair.ac.id a Radiology Resident, Faculty of Medicine Universitas Airlangga, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia b Radiology Department Consultant, Faculty of Medicine Universitas Airlangga, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia c Ophthalmology Department Consultant, Faculty of Medicine Universitas Airlangga, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia d Pathology Anatomy Department Consultant, Faculty of Medicine Universitas Airlangga, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia e Faculty of Medicine Universitas Airlangga, Faculty of Medicine Universitas Airlangga, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia ABSTRACT Orbital lymphoma represents a small fraction of all systemic lymphomas that has been accounted for approximately in 1-2% of non-Hodgkin lymphomas (NHL). Some diagnostic delays might be occurred due to the fact that there are non-specific clinical signs. Furthermore, an orbital CT scan can determine the location of the orbital mass and assist in ophthalmological surgery as well as to obtain an optimal sample for an accurate diagnosis. CT scan was performed and revealed the pattern of orbital lymphoma in order to pursue the proper diagnosis. In accordance to the imaging result, immunohistochemical studies were performed from biopsy specimens of all three patients. It showed that there were a non-Hodgkin's lymphomas originating in the orbit, lids, and oculi adnexa. Keywords: orbital lymphoma; non-Hodgkin lymphomas; orbital CT scan 1.BACKGROUND Orbital lymphoma is a type of non-Hodgkin lymphoma (NHL) that can originate from the conjunctiva, lacrimal gland, eyelid soft tissue, or extraocular muscles. Nevertheless, it has mostly occurred in the extraconal. 1 Some studies showed that the most common lymphoma has been aroused from the tissues around the eye. It is a low-grade B-cell lymphoma and is also known as Extranodal Marginal Zone Lymphoma (MALT). Sjö LD et al. (2009) stated that more than 50% of orbital and ocular adnexal lymphomas originated from the MALT lymphoma subtype; however, diffuse large B-cell lymphoma (DLBCL) predominated in the intraocular lymphoma. 2,3 Furthermore, these lymphomas have been aroused in lymphoid tissue and acquired at certain extranodal sites because of chronic inflammation or autoimmune disorders. Such tumors were likely to be found in the 5 to 7 decades of life which were predominantly occurred in females. The occurrence of lymphoma orbital infiltration is characterized by a palpable mass’ texture can be hard or spongy. 2 As a result, the emergence of pain is an uncommon symptom. 4 In terms of characterizing and evaluating the extent of this disease, imaging plays an important role. In addition, proper consideration should be accounted to the anatomical compartment involved and the tissue which was originated from the aroused neoplasm. This mechanism is conducted to evaluate the imaging of all orbital disease processes. In this study, the following features as the clinical, histopathological, and imaging of orbital lymphoma in the adult population were discussed. 5 2. CASE 2.1. CASE 1 A 50-years-old woman presented with bilateral orbital swelling and pain. Moreover, an orbital CT scan has been performed and revealed a solid extraconal mass found in the lateral-inferior lid of the right oculi with involvement of the right lacrimal gland and the inferior lid of the left oculi (Figure 1). In 80 www.ijrp.org IJRP 2022, 100(1), 80-84; doi:.10.47119/IJRP1001001520223131