Research Article Journal of Clinical and Medical Reviews Anthocleista Djalonensis: A Review of Its Ethnobotanical, Phytochemical and Pharmacological Potentials Adebayo A. OGUNBOYE 1* , Olamide O. CROWN 2 1 Phytomedicine, Biochemical and Molecular Pharmacology and Toxicology Laboratories Department of Biochemistry, School of Life Sciences, Federal University of Technology, P. M. B. 704, Akure,Nigeria. 2 Department of Chemistry, Physics and Atmospheric Sciences. Jackson States University, Jackson, Mississippi, USA. *Corresponding Author: Adebayo A. OGUNBOYE, Phytomedicine, Biochemical and Molecular Pharmacology and Toxicology Laboratories, Department of Biochemistry, School of Life Sciences, Federal University of Technology, P. M. B. 704, Akure, Nigeria. Received Date: 15 July 2022 Accepted Date: 25 July 2022 Published Date: 3 August 2022. Citation: Adebayo A.O, Olamide O.C, (2022). Anthocleista Djalonensis: A Review of Its Ethnobotanical, Phytochemical and Pharmacological Potentials. Journal of Clinical and Medical Reviews. 1(1). Copyright: © 2022 Adebayo A. OGUNBOYE, this is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Anthocleista djalonensis is widely used in African folk medicine to treat conditions. This review aims to provide for the first time ethnopharmacological information while critically evaluating the traditional medicinal uses, chemical constituents and pharmacological activities so as to unveil opportunities for future research. Ethno-medical uses of the, leaf, root and stem bark extracts include treatment of wound, constipation, diarrhoea, dysentery, abdominal pain, hepatitis, jaundice, cirrhosis, fungal skin infection, filarial worm infections, acute inflammation and boils on skin, anti-diabetes, antimalarial, anti-pyretic, anthelmintic, antimycobacterial, and anti-bacterial properties. Some of the compounds isolated are phthalide and xanthones sweroside, djalonenoside, lichex-anthone, stigmasterol, 3-oxo- Δ4′5-sitosterone, sitosterol, ursolicacid, djalonensin and D-(þ)-bornesitol. The pharmacological activities of the leaf, stem bark and root has been scientifically proven by in vitro and in vivo studies. The cytotoxic activity of the crude methanol extracts obtained from the stem, roots and leaves and three natural plant constituents (djalonenol, sweroside and djalonensone respectively) isolated from the extract had been evaluated in vitro. This review has been able to show the therapeutic potentials of Anthocleista djalonensis through its ethnobotanical and pharmacological uses. Keywords: leaf, root and stem bark extracts include treatment of wound, constipation, diarrhoea, dysentery, abdominal pain, hepatitis, jaundice.