Open Forum Infectious Diseases MAJOR ARTICLE DOI: 10.1093/ofid/ofad090 1 Preservation of the innate immune response to Clostridioides difficile infection in hospitalized immunocompromised patients Marcela Banegas 1,2 , Javier Villafuerte-Gálvez 1,2 , Rodrigo Paredes 2,3 , Rebecca Sprague 1,2,4 , Caitlin Barrett 1,2,4 , Anne J. Gonzales-Luna 5 , Kaitlyn Daugherty 1,2 , Kevin W. Garey 5 , Hua Xu 1 , Qianyun Lin 6 , Lamei Wang 1,7 , Xinhua Chen 1 , Nira R. Pollock 2,4,8 , Ciarán P. Kelly 1,2 , Carolyn D. Alonso 2,4 1 Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA; 2 Harvard Medical School, Boston, Massachusetts, USA; 3 Division of Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA; 4 Division of Infectious Diseases, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA; 5 Department of Pharmacy Practice and Translational Research, University of Houston College of Pharmacy, Houston, Texas, USA; 6 Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, Beijing, China; 7 College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi Province, China; 8 Department of Laboratory Medicine, Boston Children’s Hospital, Boston, Massachusetts, USA Background. Clostridioides difficile infection (CDI) immune response is influenced by the innate and adaptive (humoral) immune systems. Our prior research found attenuated humoral responses to C. difficile in immunocompromised hosts (ICHs) with CDI. We sought to evaluate whether the innate immune response to CDI was influenced by ICH status. —————————————————————————————————————————— Corresponding Author: Carolyn D. Alonso, MD, FIDSA, Director, Immunocompromised Host Infectious Diseases Service, BIDMC, Assistant Professor of Medicine, Harvard Medical School, Division of Infectious Diseases, Department of Medicine, Beth Israel Deaconess Medical Center, 110 Francis Street, Suite GB, Boston, MA 02215, USA Email: calonso@bidmc.harvard.edu © The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com ACCEPTED MANUSCRIPT Downloaded from https://academic.oup.com/ofid/advance-article/doi/10.1093/ofid/ofad090/7046105 by guest on 20 February 2023