Int.J.Curr.Microbiol.App.Sci (2020) 9(7): 600-608 600 Original Research Article https://doi.org/10.20546/ijcmas.2020.907.067 Successful Management of Jaundice in a Dog using Therapeutic Blood Transfusion Tarun Kumar 1* , Kanchan Arya 2 , Pardeep Dhillon 2 , Jai Bhagwan 2 , Maneesh Sharma 1 , Deepika Kumari 2 , Divya Agnihotri 1 and V. K. Jain 1 1 Veterinary Clinical Complex, 2 Department of Veterinary Medicine, Lala Lajpat Rai University of Veterinary and Animal Sciences, Hisar-125004 (Haryana), India *Corresponding author ABSTRACT Introduction Jaundice is a yellowish discoloration of the skin and mucous membranes caused by hyperbilirubinemia. Hyperbilirubinemia can occur due to prehepatic (usually hemolysis), posthepatic (due to obstructive or functional cholestasis), or hepatic causes. Hyperbilirubinemia in hepatic disease is caused by decreased uptake of unconjugated bilirubin and/or decreased conjugation by the hepatocytes (Sevelius, 1995) therefore, hyperbilirubinemia is usually associated with a severely impaired hepatic function. Prehepatic jaundice is usually caused by the release of hemoglobin associated with RBC lysis. High plasma levels of unconjugated (free) bilirubin are derived from massive hemoglobin breakdown. International Journal of Current Microbiology and Applied Sciences ISSN: 2319-7706 Volume 9 Number 7 (2020) Journal homepage: http://www.ijcmas.com An adult 1.5-year old male Pitbull dog was presented to the Department of veterinary clinical complex, LUVAS, Hisar, Haryana, with a history of anorexia, high fever, deep yellow colored urine and itching on ventral abdomen for one month. Clinical examination showed pale mucus membranes with increased respiration rate, however, electrocardiogram (ECG) was found normal. The hematological findings showed severe microcytic hypochromic anemia, neutrophilic leukocytosis, marked increase in total bilirubin values suggestive of jaundice. Bloodsmear examination was found negative for hemoprotozoan. The animal was treated with a combination therapy comprising of a single dose of Imidocarb dipropinate (5.5 mg/kg, b.wt, SC) and Ceftrixone-Tazobactum (25 mg/kg, b.wt, IM) for 5 days. Blood transfusion was conducted on the second day to correct severe anemia Supportive treatment included antiemetics, hepato- protectants, hematinic, multivitamins, amino acids and fluid therapy. Re- evaluation of various blood parameters after 7 days of treatment revealed marked improvement. Keywords Dog, Jaundice, Anemia, Blood Transfusion Accepted: 05 June 2020 Available Online: 10 July 2020 Article Info