How to Cite Permana, A. T., Suroto, N. S., Parenrengi, M. A., Bajamal, A. H., Lestari, P., & Fauzi, A. A. (2022). Current update on stroke ischemic management: Stem cell as emerging therapy. International Journal of Health & Medical Sciences, 5(1), 122-128. https://doi.org/10.21744/ijhms.v5n1.1851 ISSN 2632-9433 Submitted: 09 November 2021|Revised: 18 December 2021| Accepted: 27 January 2022 122 Current Update on Stroke Ischemic Management: Stem Cell as Emerging Therapy Andhika Tomy Permana Department of Neurosurgery, Faculty of Medicine Universitas Airlangga – Dr. Soetomo Academic General Hospital, Surabaya, Indonesia Email: andhika.tomy@gmail.com Nur Setiawan Suroto Department of Neurosurgery, Faculty of Medicine Universitas Airlangga – Dr. Soetomo Academic General Hospital, Surabaya, Indonesia Email: setiawan.dr@gmail.com Muhammad Arifin Parenrengi Department of Neurosurgery, Faculty of Medicine Universitas Airlangga – Dr. Soetomo Academic General Hospital, Surabaya, Indonesia Email: muhammad.arifin@fk.unair.ac.id Abdul Hafid Bajamal Department of Neurosurgery, Faculty of Medicine Universitas Airlangga – Dr. Soetomo Academic General Hospital, Surabaya, Indonesia Email: hfbajamal@gmail.com Pudji Lestari Department of Public Health Science and Preventive Medicine, Faculty of Medicine Universitas Airlangga – Dr. Soetomo Academic General Hospital, Surabaya, Indonesia Email: pulesja@gmail.com Asra Al Fauzi Department of Neurosurgery, Faculty of Medicine Universitas Airlangga – Dr. Soetomo Academic General Hospital, Surabaya, Indonesia Corresponding author email: asraalfauzi@gmail.com Abstract---Stroke is one of the most important causes of morbidity and mortality worldwide, with survivors subjected to long-term disability. Stroke is classified as ischemic and hemorrhagic. 87 % of strokes are classified as ischemic. Except for thrombolytic therapy, there is no established treatment to reduce the neurological deficits caused by an ischemic stroke. Therefore, it is necessary to develop new therapeutic strategies designed to improve neurological functions after ischemic stroke. Stem cell-based therapies aim to promote neurogenesis and replacement of lost neurons or protect surviving neurons to improve neurological recovery. Further understanding of the mechanisms by which the stem cells exert their beneficial effect could potentially revolutionize the field. The next decade of stem cell research in stroke needs to focus on. Although still in need of exploration, stem cell treatments for stroke may offer ways to protect and replace neurons to improve outcomes for stroke patients. Keywords---clinical trial, emerging therapy, neuroregeneration, stem cell, stroke ischemic.