How to Cite: Kumbhar, A. B., Chaudhari, P. D., & Karimunnisa, S. (2022). Nanocomposite based drug delivery for periodontal disease. International Journal of Health Sciences, 6(S9), 2982–2995. https://doi.org/10.53730/ijhs.v6nS9.13188 International Journal of Health Sciences ISSN 2550-6978 E-ISSN 2550-696X © 2022. Manuscript submitted: 9 May 2022, Manuscript revised: 18 July 2022, Accepted for publication: 27 August 2022 2982 Nanocomposite based drug delivery for periodontal disease Kumbhar Amol B. Department of Pharmaceutics, PES’s, Modern College of Pharmacy, Pune Corresponding author email: kumbharamol123@gmail.com Dr. Chaudhari Pravin D. Professor, PES’s, Modern College of Pharmacy, Pune Dr. Shaikh Karimunnisa Associate Professor, PES’s, Modern College of Pharmacy, Pune Abstract---Periodontal disease is the term used to describe some pathological conditions characterized by degeneration and inflammation of gums, periodontal ligaments, alveolar bone, and dental cementum. Periodontal disease involves destruction of alveolar bone around the teeth leading to defects or rather loss of the tooth if left untreated. This condition is caused by a chronic, mixed infection of Gram-negative and Gram-positive bacteria. Chlorhexidine (CHX) gluconate is an antiseptic, antifungal and bactericidal agent. CHX inhibits plaque formation by binding to anionic salivary glycoproteins and bacteria. Nano Hydroxyapatite (nHAP) is calcium phosphate in morphology and composition like the human hard tissues. Delivery of medications directly into the periodontal pockets alters the inflammatory response and reduces the pathogenic microbiota, an aspect which has attracted great interes. Result: The CHX Nanocomposites were non-toxic to human cells and promoted cell adhesion, proliferation, and spreading. The CHX Nanocomposites were found to be satisfactory in all respects, and CHX encapsulated in nanocomposites may be attractive candidates for the treatment of periodontal disease. Keywords---Periodontitis, Nanocomposite, CHX, PGS, nHAP. 1. Introduction Periodontal disease is a word that refers to a group of diseases marked by the degeneration and inflammation of the gums, periodontal ligaments, alveolar bone, and dental cementum. It's a localized inflammatory reaction brought on by a