         !!"  # $%&’()% *&+ ,--...&%&’()%/*&+*0      Full Length Research Paper Efficacy and safety of Ziabites (an Iranian traditional medicine compound) on glycemic control in type 2 diabetic patients Majid Asghari 1 , Mohsen Naseri 1 *, Zari Sabet 1 , Ali Davati 2 , Mohammad Kamalinejad 3 , Mohammad Reza Jalali-Nadoushan 4 , Akbar Shaali 5 , Sasan Doost 5 and Masoud Alamshekan 5 1 Traditional Medicine Clinical Trial Research Center, Shahed University, P. O. Box 14179-53836, Tehran, Iran. 2 Department of Social Medicine, School of Medicine, Shahed University, P. O. Box 14179-53836, Tehran, Iran. 3 Department of Internal medicine, Shahid Mostafa Khomeini Hospital, Shahed University, P. O. Box 14179-53836, Tehran, Iran. 4 Department of Pathology, School of Medicine, Shahed University, P. O. Box 14179-53836, Tehran, Iran. 5 Department of Pharmacognosy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, P. O. Box 14179-53836, Tehran, Iran. Accepted 10 December, 2012 This study was designed to evaluate the efficacy and safety of Ziabites on glycemic control in type 2 diabetic patients. The samples consisted of 31 subjects and the doses of Ziabites were equally administered orally in the form of capsule before the breakfast, lunch and dinner. The doses were given for 4 weeks. Ziabites capsule contains Portulaca oleracea L. Rhus coriaria L. and Punica granatum L. The efficacy was assessed on the basis of the following parameters: fasting blood glucose (FBG), 2 h postprandial plasma glucose (2hppG), serum fructosamine, triglyceride (TG) and total cholesterol (Tc) levels. Also, side effects were assessed by history and physical and biochemical examinations. All of the assays were performed on the starting day of study and after 4 weeks. After 4 weeks of treatment with Ziabites capsule, there was a significant decrease (P<0.05) in mean FBG and 2hppG levels when compared with its levels on starting day. Data of mean serum fructosamine levels, showed no significant different between the starting day and after 4 weeks. Also, the reductions of mean serum TG and Tc levels after treatment, were not significant (P>0.05). This study indicated that Ziabites capsule is effective in decreasing fasting and postprandial plasma glucose levels among type 2 diabetic patients without any side effects. Key words: Ziabites, Portulaca oleracea L., Rhus coriaria L., Punica granatum L., diabetes mellitus. INTRODUCTION "Diabetes mellitus (DM) is a chronic disorder charac- terized by the impaired metabolism of glucose and other energy-yielding fuels as well as the late development of vascular and neuropathic complications" (Goldman and Ausiello, 2008). "The worldwide prevalence of DM has risen dramatically over the past two decades, from an estimated 30 million cases in 1985 to 285 million in 2010. Based on current trends, the International Diabetes 12**+’)0 &-,* 3(&) "&+*)4!,&,’&%)* 5  6&7 