Journal of Biomedical and Pharmaceutical Research Available Online at www.jbpr.in CODEN: - JBPRAU (Source: - American Chemical Society) PubMed (National Library of Medicine): ID: (101671502) Index Copernicus Value 2018: 88.52 Research Article Volume 8, Issue 6: November-December: 2019, 73-87 ISSN (Online): 2279-0594 ISSN (Print): 2589-8752 73 | Page FORMULATION AND EVALUATION OF NIFEDIPINE SUSTAINED RELEASE TABLETS BY USING DIFFERENT POLYMERS Shraddha Pawan Pareek 1* , Sunil Kumawat 2 , Vijay Sharma 2 , Devender Sharma 2 , Devendra Singh Rathore 2 1* Research Scholar, Goenka College of Pharmacy, Lachhmangarh, Sikar, Rajasthan (India) 2 Department of Pharmaceutics, Goenka College of Pharmacy, Lachhmangarh, Sikar, Rajasthan (India) Article Info: Received 02 September 2019; Accepted 18 November. 2019 DOI: https://doi.org/10.32553/jbpr.v8i6.684 Address for Correspondence: Shraddha Pawan Pareek Conflict of interest statement: No conflict of interest ABSTRACT: Oral drug delivery has been known for many years because the most generally utilized route of administration among all the routes that are explored for the general delivery of medication via various pharmaceutical products of different dosage forms. The reason that the oral route achieved such quality could also be partly attributed to its simple administration moreover because the ancient belief that by oral administration the drug is well absorbed because the food stuffs that area unit eaten daily. In fact the event of a pharmaceutical product for oral delivery, no matter its physical kind involves variable extents of optimization of dose kind characteristics at intervals the inherent constraints of GI physiology. The rationale for development of a extended release formulation of a drug is to enhance its therapeutic benefits, minimizing its side effects while improving the management of the diseased condition. The aim of the present investigation is to formulate and evaluate matrix tablets of Nifedipine using a mixture of polymers in view to sustain the drug release, reduce frequency of administration and improved patient compliance. In this research paper all evaluation parameter and stability studies also well discussed in well manner. Keyword Matrix Tablets, Coating, Novel Drug Delivery System, Sustained Release Tablets INTRODUCTION: Sustained- release dosage forms it is defined as “any drug or dosage form modification that prolongs the therapeutic activity of the drug”. Sustained release formulations can offer many pharmacokinetic and Pharmacodynamic advantages over conventional dosage forms, including maintenance of constant therapeutic levels for a longer period of time and reduction of fluctuations in plasma drug concentrations. Sustained release formulations can reduce the risk of treatment failure due to inadequate dosing of antibiotics. Nifedipine has bioavailability of 45-56%, protein binding of 92-98% and its half-life is about 2 hours and it undergoes gastrointestinal and hepatic metabolism So, In the present study, aim is for preparation and evaluation of sustained release matrix tablets of Nifedipine, in order to overcome first-pass effect, dose related side effects, dosing frequency, problems in disease control and many other difficulties. MATERIALS AND METHOD Chemicals and Reagents Nifedipine Hydrochloride was supplied by Glow Pharma Ltd, Vasai, Maharashtra and Hydroxypropylmethylcellulose K100M, Ethylcellulose, Polyvinyl pyrollidone K-30, Magnesium Stearate, Aerosil, Lactose, Talc was also supplied by Glow Pharma Ltd, Vasai, Maharashtra Preformulation Studies Preformulation testing is the first step in rational development of dosage forms of a drug Substance. Preformulation study is the process of optimizing the delivery of drug through Determination of physicochemical properties of the excipients that could affect drug performance and development of as efficacious, stable and safe dosage form. 1 It provides a framework for the drug combination with pharmaceutical excipients in the dosage form. Determination of λ max of Nifedipine was dissolved