25th European Congress of Psychiatry / European Psychiatry 41S (2017) S303–S364 S329 explained to why they had been admitted involuntarily. Also, there was a significant difference in AES scores between those who were and were not given an explanation for admission. In addition, psy- chiatrists more often reported that the involuntary admission wor- sened the therapeutic relationship which was significantly associa- ted with involuntary admission that was not explained to patients. Discussion The results of our study shows that patients admitted involuntarily often feel disappointed with staff and mental health system. It could lead to feeling of hopelessness, frustration and low self-esteem. If explained, some patients who present with risk to self might accept voluntary admissions, that will improve thera- peutic alliance with psychiatrists and increase satisfaction from hospitalization. Result of this study could improve the decision making process for involuntary admissions. Disclosure of interest The authors have not supplied their decla- ration of competing interest. http://dx.doi.org/10.1016/j.eurpsy.2017.02.264 EW0651 Genetic counselling in patients with bipolar disorder–ethical challenges D. Vasile * , O. Vasiliu Central university and emergency military hospital “Dr. Carol Davila”, psychiatry, Bucharest, Romania * Corresponding author. Background Genetic counselling in psychiatric patients is almost always a challenge on multiple levels of communication, because the mental health specialist is situated between the need to validate the freedom of procreation, and the duty to inform patients about the risk of transmitting their disease to off-springs. Bipolar disorder (BPD) is reputed to be one of the most heritable psychiatric disorder, a factor that complicate even more the ethical situation. Objectives To assess how psychiatrists and psychologists conduc- ted genetic counseling for patients with BPD and the challenges that mental health professionals consider important when they need to make this type of counseling. Methods Standardized interviewing of 15 psychiatrists and psy- chologists who experienced during their clinical practice aspects of genetic counseling in patients with BPD. Results The most commonly reported problems related to the genetic counseling in bipolar patients were: lack of reliable data on family history (53.3%), amplification of patient stigmatiza- tion (46.6%), controversies in the literature on the assessment of the disease risk (40%), difficulties in maintaining a nondirective attitude (33.3%), lack of genetic counseling follow-up (33.3%), dis- proportionate interest from the partner without mental disorder, when compared to patients, in terms of aspects of genetic counse- ling (26.6%), alteration of the therapeutic relationship and patients interest in treatment (26.6%). Conclusions Genetic counseling is a challenge for mental health professionals, who must cope with the lack of reliable data on the pathogenesis of BPD, negative reactions from the patients’ partners, patient disinterest or hostility and possible negative effects on the therapeutic relationship. Disclosure of interest The presenting author was speaker for Astra Zeneca, Bristol Myers Squibb, CSC Pharmaceuticals, Eli Lilly, Janssen Cilag, Lundbeck, Organon, Pfizer, Servier, Sanofi Aventis and partici- pated in clinical research funded by Janssen Cilag, Astra Zeneca, Eli Lilly, Sanofi Aventis, Schering Plough, Organon, Bioline Rx, Forenap, Wyeth, Otsuka Pharmaceuticals, Dainippon Sumitomo, Servier. http://dx.doi.org/10.1016/j.eurpsy.2017.02.265 EW0652 Psychology feminine holiness J. Garcia-albea 1,* , M. Navas 2 1 Instituto de psiquiatría San carlos, psiquiatría, Madrid, Spain 2 Hospital universitario Infanta leonor, psiquiatría, Madrid, Spain * Corresponding author. Feminine holiness is a subject as complex as it is interesting–not least because of the very definition of the term–, in many occasions extraordinary and many others bitter, which has sparked interest throughout history, especially after the progress made on moder- nity. Objective The main objective is less to show whether there is a psychiatric, infectious, neurological or any other form of patho- logical disorder linked to the behaviour of female saints, rather to evaluate all the psychological and social aspects that result in holiness as a mental state being largely a female attribute. Material and methods For this, we have tested from birth to death, in what is possible, the lives of sixty religious women, through bio- graphies and autobiographies since they were servants, pious or holy according to ecclesiastical terminology. This set was unavoi- dable to select twelve cases, which are set out exhaustively in this study. Results and discussion Limiting ourselves to a purely psychiatric view, we can show the presence of psychopathology associated with exceptional states of consciousness, as would be ecstatic and mystical experience itself, present in most cases. We also found common psychological profiles, out of the sixty biographies and autobiographies of religious women analyzed: e.g. pain is used as a means of atonement and a way of removing the guilt of sin. We rule out major psychiatric disorders in the Santas we have analyzed. The behaviors they presented, even sometimes excessive, cannot be included in any of the current major psychiatric disorders. Disclosure of interest The authors have not supplied their decla- ration of competing interest. http://dx.doi.org/10.1016/j.eurpsy.2017.02.266 EW0653 Mental illness is an inevitable consequence of the singular diversity of human beings M. Schwartz 1,* , M. Moskalewicz 2 , E. Schwartz 3 , O. Wiggins 4 1 Texas A&M Health Science center college of medicine, Round Rock, Texas, psychiatry and humanities in medicine, West Lake Hills, USA 2 Texas A&M Health Science center college of medicine, psychiatry, Round Rock, Texas, USA 3 George Washington university school of medicine, psychiatry, Washington DC, USA 4 University of Louisville, philosophy, Louisville, KY, USA * Corresponding author. Nowadays, cosmopolitan populations increasingly applaud the broad physical, ethnic, racial, and cultural diversity of human beings. So long as we behave within sanctioned norms. This presen- tation will focus upon the above paradox: In contrast to delighting in physical, ethnic and cultural expressions of human diversity, present-day cosmopolitan societies increasingly call for conformity in behavioral and experiential realms. For example, at meetings such as this, we can freely express and celebrate racial, eth- nic, and culturally differences, but we must communicate–within remarkably narrow ranges–cordiality, spontaneity, agreeableness, respectful disagreement and tact. And if we cannot?? We propose that the phenomenon of mental illness arises as a consequence of the phenomenon of human diversity coming up against constraints and limitations in mental and behavioral realms. This presentation will focus upon evolutionary, genetic, biological, anthropological, historical and cultural aspects of the primary role that human diver- sity plays in mental illness. We will discuss the adaptive origins and strengths associated with the extraordinary diversity of humans (and our pets/domestic animals) as well accompanying vulnera- bilities. For example, diversity of skin pigmentation has enabled humans to extend across the globe. A consequence however, is enhanced vulnerability to skin cancer for some with fair skin and