Orthotopic Liver Transplantation With Elderly Donors (Over 80 Years of Age): A Prospective Evaluation P.A. Cascales-Campos a , P. Ramírez a , M.R. González-Sánchez a , F. Alconchel a, *, L.A. Martínez-Insfran a , F. Sánchez-Bueno a , R. Robles a , J.A. Pons b , Á. Vargas b , J. Sanmartín c , M. Royo-Villanova c , and P. Parrilla a a Liver Transplantation Unit, Department of Surgery, Hospital Clínico Universitario Virgen de la Arrixaca-IMIB Arrixaca, Murcia, Spain; b Department of Hepatology, Hospital Clínico Universitario Virgen de la Arrixaca-IMIB Arrixaca, Murcia, Spain; and c Intensive Care Department, Hospital Clínico Universitario Virgen de la Arrixaca-IMIB Arrixaca, Murcia, Spain ABSTRACT Background. Our main objective was to assess the clinical outcomes obtained in a single orthotopic liver transplant (OLT) hospital with donors 80 years of age compared to a control group of patients subjected to OLT during the same period of time with donors who were under 65 years of age. Methods. A prospective analysis was carried out on all the OLTs performed using liver grafts from donors in a state of brain death and with an age of 80 years (study group) between April 2007 and January 2015. The results of the study group (n ¼ 36) were compared with those of a control group of patients less than 65 years of age receiving transplants with grafts. Results. A total of 51 potential donors 80 years were assessed, with a total of 36 liver transplants being carried out and their results were compared with a control group of 283 patients receiving transplants. The median follow-up time of the patients in the series was 36 months (range: 24e120 months). Graft survival at 1, 2, and 3 years was 77%, 72%, and 62%, respectively, among the patients in the study group and 79%, 73%, and 65% among the patients in the control group, and there were no statistically significant differences. Patient survival at 1, 2, and 3 years was 86%, 82%, and 75%, respectively, among the patients in the study group and 82%, 76%, and 72% among the patients in the control group, also without there being any statistically significant differences. Conclusions. There is no age limit for liver transplant donors. The use of octogenarian donors makes it possible to increase the pool of donors while providing enough safety for the recipient. O RTHOTOPIC liver transplant (OLT) is the standard of care for a group of liver diseases in their final stage and the best treatment in patients diagnosed with hepato- cellular carcinoma (HCC) associated with cirrhosis [1]. There is currently a shortage of organs available for patients on the waiting lists due to the existence of a lower number of donors compared to OLT needs, which means the mor- tality rates of patients on the liver transplant waiting list are increasing [2]. The management of treatments prior to OLT, which act as a bridge, and prioritization policies play a fundamental role in those patients who have oncologic indications, especially in patients with hepatocarcinoma, faced with the possibility of tumor progression [3e5]. With the objective of increasing the number of donors, specific policies have been put into place for the donor, such The first 2 authors contributed equally to this work. *Address correspondence to Felipe Alconchel, MD, Depart- ment of Surgery, Hospital Clínico Universitario Virgen de la Arrixaca Carretera Madrid-Cartagena s/n, El Palmar, Murcia 30120, Spain. E-mail: cascalescirugia@gmail.com 0041-1345/18 https://doi.org/10.1016/j.transproceed.2018.08.005 ª 2018 Elsevier Inc. All rights reserved. 230 Park Avenue, New York, NY 10169 3594 Transplantation Proceedings, 50, 3594e3600 (2018)