PLATFORM PRESENTATIONS Sunday, November 11, 2018, 11:00 am e 12:00 pm MORNING PLATFORM PRESENTATIONS PL01 Comparison of Cytology and Molecular Adequacy Rates between Two Large Thyroid FNA Practices Reveals Differing Advantages for Cytology and Molecular Testing Michael Landau, MD, Thomas Pearce, MD, PhD, Jenna Wolfe, BS, SCT(ASCP), Sally Carty, MD, Linwah Yip, MD, Kelly McCoy, MD, Mitchell Tublin, MD, Shane LeBeau, MD, N. Paul Ohori, MD. University of Pittsburgh Medical Center, Pittsburgh, PA Introduction: At our institution, most thyroid FNAs are performed in two settings, one in Endocrinology and the other in Radiology. Both use ultrasound guidance and in both settings the processing and interpretation are performed by the same cytotechnologists and cytopathologists. However, there are differences that include Endocrinology’s routine use of rapid on-site evaluation (ROSE) for specimen adequacy, while Radiology uses ROSE in less than 10% of FNAs. Also, Radiology uses a 3-inch needle with a stylet, while Endocrinology uses a 1.5-inch needle without a stylet. In this study, we compared the diagnostic cytology and molecular adequacy rates of the two practices. Materials and Methods: This study was approved as a quality assurance project. All thyroid FNA specimens with molecular test results from Endocrinology and Radiology practices from September 2008 to December 2016 were included. The following parameters were collected: cytology diagnoses, cytology adequacy statements (satisfactory or unsatisfactory), and molecular adequacy statements (molecular adequate, molecular limited, or molecular failure). The molecular information was stratified according to the Sanger sequencing era (7-gene test) and the next-generation sequencing era (ThyroSeq v1 and v2). Statistical analysis was performed by Fischer’s Exact Test. Results: A total of 10,407 FNA specimens were retrieved: 5,810 from Endocrinology and 4,597 from Radiology. Endocrinology and Radiology had similar rates of thyroid FNA results that were positive for malignancy (3.6% vs. 3.8%, pZ0.50). Regarding cytology specimens, Endocrinology had a significantly lower unsatisfactory rate than Radiology (5.3% vs. 10.0%, p<0.001). Conversely, Radiology had a significantly lower molecular failure rate (6.6% vs. 9.2%, pZ0.002) and molecular limited rate (6.4% vs. 10.6%, p<0.001). Table 1 shows the results of the Sanger sequencing era and the next-generation sequencing era. Conclusions: Study results suggest that differences in the two FNA acquisition methods are associated with an inverse relationship between diagnostic cytology and molecular adequacy rates. PL02 The CerviCusco Telecytology Conferences - 2011 to 2018: Data from Seven Years of Providing Cervical Cytology Interpretation Services in Peru Erika Escalante, Blga 1 , Nicholas Jones, BA 2 , Ronald Arpin, MS, SCT(ASCP)MB 2 , Karen Atkison, MPA, CT(ASCP) 3 , Nasera Hassan, CFIAC 4 , Nancy Joste, MD 5 , Carrie Marshall, MD 6 , Nora Morgenstern, MD 7 , Cherie Paquette, MD, MS 8 , Brenda Sweeney, SCT(ASCP)MB 2 , William Tench, MD 3 , Patricia Tiscornia-Wasserman, MD 9 , Barbara Winkler, MD 10 , David Wilbur, MD 2 . 1 CerviCusco, Cusco, Peru; 2 Massachusetts General Hospital, Boston, MA; 3 Burlington, NC; 4 Duke University, Durham, NC; 5 University of New Mexico Health Science Center, Albuquerque, NM; 6 University of Colorado School of Medicine, Aurora, CO; 7 New York Presbyterian Queens, New York, NY; 8 Brown University - Women and Infants Hospital, Providence, RI; 9 Columbia University, New York, NY; 10 CareMount Medical Group, Mount Kisco, NY Introduction: Using simple web-conferencing software, cervical telecytol- ogy services are provided to a remote screening clinic in Cusco. Weekly conferences are staffed by cytopathologists and cytotechnologists with slides remotely presented by a cytotechnologist in Peru. Analysis of 7 years of data shows the effectiveness of the process. Materials and Methods: Teleconferences began in 2011 and have taken place to the present. Final interpretations are achieved via consensus of the group. Data collected and analyzed over that period includes number of cases reviewed, number of interpretations in each Bethesda category, the correlation of screening and final conference interpretations measured over time, and the correlation of biopsy results where available. Kappa statistics were calculated to compare screening and final cytologic interpretations. Results: 168 conferences were held in the seven-year period. As of April 2018, 1622 cases screened as potentially abnormal have been reviewed. Results show 216 NILM, 4 unsatisfactory, 289 ASC-US, 204 ASC-H, 436 LSIL, 386 HSIL, 40 AGC, 30 cancer, and 17 miscellaneous/defer. Correlation of screening and final consensus results continuously improved over time (see figure A) weighted Kappa statistic was 0.8 which is considered "excellent." Cytology - available biopsy correlation (positive cytology results only) showed 96% accuracy with 24/25 cases correlating within 1 category. The remaining case was interpreted as LSIL with cancer on biopsy, which could also be considered a "hit" as that result led to appropriate triage. Conclusions: The CerviCusco experience shows that remote interpretation via a simple telecytology platform is not only feasible, but shows high Table 1 2213-2945/$36 Ó 2018 Published by Elsevier Inc. on behalf of American Society of Cytopathology. https://doi.org/10.1016/j.jasc.2018.06.006 Available online at www.sciencedirect.com ScienceDirect journal homepage: www.jascyto.org/ Journal of the American Society of Cytopathology (2018) 7, S83eS89