International Journal of Research in Medical Sciences | June 2020 | Vol 8 | Issue 6 Page 1 International Journal of Research in Medical Sciences Dhar SK et al. Int J Res Med Sci. 2020 Jun;8(6):xxx-xxx www.msjonline.org pISSN 2320-6071 | eISSN 2320-6012 Original Research Article Cerebrospinal fluid analysis in dengue in a tertiary care center Srikant Kumar Dhar, Udaybhanu Rout*, Naqash Nadar Suse, Nikhil Rajendra Arve, Naresh Yennam, Rakesh Keshari Swain INTRODUCTION Dengue is found in tropical and subtropical areas around the world, predominantly in urban and semi-urban regions. 1 The disease is caused by a virus due to family Flaviviradae that is spread by Aedesmosquitoes. 2 Some 2.5 billion people two fifths of the world's population in tropical and subtropical countries are at risk and an estimated 50 million dengue infections occur worldwide annually. 3,4 Dengue and DHF is endemic in more than hundred countries in the WHO regions of Africa, the Americas, the Eastern Mediterranean, the Western Pacific and east Asia but The South East Asia and Western Pacific regions are the most seriously affected. 4 Epidemics of dengue are rising in frequency. During epidemics, infection rates among those who have not been previously exposed to the virus are often 40% to 50% but can also increase to 80% to 90%. Some recent reports indicate that the clinical profile of dengue is changing. Neurological manifestations are being reported very frequently. While the actual incidence of various neurological complications is not certain, the reported incidence of encephalopathy and encephalitis, the most common neurological manifestations of dengue. Department of Medicine, IMS and SUM Hospital, Siksha “O” Anusandhan University, K8, Kalinganagar, Bhubaneswar, Odisha, India Received: 18 April 2020 Accepted: 29 April 2020 *Correspondence: Dr. Udaybhanu Rout, E-mail: udaybhanu.rout@gmail.com Copyright: © the author(s), publisher and licensee Medip Academy. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. ABSTRACT Background: Clinical profile of dengue is variable including neurological manifestations like encephalopathy and encephalitis which are not being reported very frequently. This study is an attempt to know the cerebrospinal fluid (CSF) finding in dengue infected patients with neurological manifestations in a tertiary care hospital Eastern Odisha. Methods: Study conducted from August 2018 to July 2019 comprising of 100 dengue seropositive (NS1/IgM/IgG) patients of age >15 years in IMS and SUM Hospital. Results: A total of 100 (66 boys and 34 girls) hospitalised patients (Age >15 years) diagnosed as dengue were enrolled in our study. Total 20 cases Cerebrospinal fluid analysis has been done in which we found 70% (13 cases) unclassified viral meningitis, 15% (3 cases) bacterial meningitis, 5% (1 case) tuberculous meningitis, 5% (1 case) herpes encephalitis and 5% (1 case) Japanese encephalitis. Neurological manifestations in all dengue sero positive cases (100) found 30% headache, 18% altered sensorium, 5% seizure, 4% syncope, 3% papilloedema, 1% CN palsy and 11% meningeal signs. Conclusions: Dengue meningoencephalitis must be thought of in differentials of all febrile encephalopathy. This study brings out the incidence of different meningoencephalitis on the bases of CSF analysis including coinfections. So in dengue patients with neurological manifestation should do CSF analysisfor better outcome of a disease. Keywords: Cerebrospinal fluid, Dengue, Headache, Meningeal signs, Meningoencephalitis, Neurological manifestations DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20202046