CASE REPORT OPEN ACCESS Journal of the College of Physicians and Surgeons Pakistan 2022, Vol. 32(06): 814-816 814 Fibrolipoma of Tongue: A Rare Entity Salima Mansoor 1 , Nausheen Yaqoob 1 , Anila Haneef 1 , Sunder Sham 1 and Asif Ali Arain 2 1 Department of Histopathology, The Indus Hospital, Karachi, Pakistan 2 Department of ENT, The Indus Hospital, Karachi, Pakistan ABSTRACT Lipomas are benign mesenchymal tumors that comprise almost one-half of all soft tissue tumors. Lipomas can occur at any site where fat cells are present but are rare in the oral cavity, especially the tongue, which is a very rare site. Lipoma has several variants. Fibrolipoma is a rare variant and accounts for 25–40% of lipomas of the tongue. In only 14 cases, the diagnosis of fibrolipoma has been made histologically. Most cases of lipomas occur above 40 years of age. Herein, we report a case of fibrolipoma of the tongue in a young female of 18 years. The patient presented with complaint of swelling on the dorsum of the tongue for 8 years. The swelling was surgically excised and microscopically a diagnosis of fibrolipoma was made. In conclusion, oral lipomas especially lingual lipomas are a rare entity. Although oral lipomas mostly occur above 40 years of age, they can occur at a younger age. Key Words: Fibrolipoma, Tongue, Histopathology. How to cite this article: Mansoor S, Yaqoob N, Haneef A, Sham S, Arain AA. Fibrolipoma of Tongue: A Rare Entity. J Coll Physicians Surg Pak 2022; 32(06):814-816. INTRODUCTION Lipomas are benign mesenchymal tumors that are very common and are comprised of mature adipocytes. They usually grow slowly and form a lobulated mass surrounded by a capsule. They can arise from almost all organs in the body where fat cells are present and may be well encapsulated or appear as infiltrating lesions. 1,2 Lipomas rarely occur in the oral cavity. The tongue is an infrequentsiteforlipomas. 2 Ofalltonguetumors,lipomasaccount for only 0.3% of cases. 3 Lipomas of the tongue may develop as a solitary lesion or can occur as a manifestation of syndromes such as Gardner’s syndrome or hereditary multiple lipomatosis. 1,4 There are several variants of lipoma. 2 In contrast to simple/conven- tional lipoma, other variants of lipoma occur less frequently. 5 Fibrolipoma is also a rare variant that sometimes may cause suspi- cion of infiltrating lesions. 5 It can involve various sites in the oral cavity including lips, buccal mucosa, palate, and tongue. 6,7 In this case report, we present a case of fibrolipoma of the tongue in a young girl where the diagnosis was solely made through histo- pathological examination. CASEREPORT An 18-year female was referred from family medicine to Otolaryn- gologydepartmentwiththecomplaintofswellingonthedorsum ofthetonguefor8years.Theswellingwaspainless,pinkincolor, non-tender and gradually increased in size. Correspondence to: Dr. Salima Mansoor, Department of Histopathology, The Indus Hospital, Karachi, Pakistan E-mail: sal33ma@hotmail.com ..................................................... Received: August 01, 2020; Revised: November 22, 2020; Accepted: December 19, 2020 DOI: https://doi.org/10.29271/jcpsp.2022.06.814 The patient did not have a significant past medical or surgical history. Family history was also unremarkable for any tumors. The patient did not seek any treatment in the past as the swellingwaspainlessandthepatient’sfamilyhadalowsocioe- conomicstatus. On examination, a well-demarcated swelling was identified which was pink in color, measuring approximately 3 × 3 cm withnoulcerationorinflammation(Figure1).Theswellingwas non-tender and firm on palpation. There was no palpable lymphadenopathy. The differentials included hemangioma, lymphangioma, and mucocele. A decision was made to excise thelesion. Figure 1: Mass located at the anterior third of the tongue. Preoperative investigations including complete blood count, serum electrolytes, PT, APTT, renal function tests, and blood glucose levels were all within normal limits. The patient was operated and the lesion was shelled out with no adhesion to the surrounding structures. Post-operatively, the patient remained stable and did not develop any postoperative complications.