Acta Scientific Gastrointestinal Disorders (ISSN: 2582-1091) Volume 4 Issue 11 November 2021 Perforated Peptic Ulcer: Surgical Management in the University Hospital of Maracaibo, Experience in 4 Years Mariana Añolis 1 *, Andrés Reyes 1 , Adel Al Awad 1,2,3 and María Matera 1,4 1 CEDIAH: Comunidad Estudiantil Para la Difusión e Investigación de la Anatomía Humana, Medicine School, Universidad del Zulia, Maracaibo, Venezuela 2 Attending on the General Surgery Service, Promote Tower Paraíso, Maracaibo, Venezuela 3 Retired Professor of Human Anatomy, Chair of Human Anatomy, Medicine School, Universidad del Zulia, Maracaibo, Venezuela 4 Free Professor of the Chair of Human Anatomy, Facultad de Medicina, Universidad del Zulia, Maracaibo, Venezuela *Corresponding Author: Mariana Añolis, CEDIAH: Comunidad Estudiantil Para la Difusión e Investigación de la Anatomía Humana, Medicine School, Universidad del Zulia, Maracaibo, Venezuela. Research Article Received: October 06, 2021 Published: October 26, 2021 © All rights are reserved by Mariana Añolis., et al. Abstract Peptic ulcer perforation is a frequent emergency, which must be resolved on time. It is closely related to Helicobacter pylori infection, smoking and the consumption of NSAIDs. The aim was to determine the surgical management and the description of the intraoperative findings in patients admitted with the diagnosis of perforated peptic ulcer in the General Surgery Service of the University Hospital of Maracaibo. The clinical history of 42 patients diagnosed with Perforated Peptic Ulcer, admitted in the General Surgery service of the University Hospital of Maracaibo in a period from January 2016 to June 2019, was reviewed. The average age of onset was 44.88 ± 6.04 years. 88.09% of the patients belonged to the male sex. On the other hand, the most frequent location of the ulcer corresponded to those of grade III, according to the classification of peptic ulcers described by Johnson. The techniques implemented for the closure correspond to, simple closure in 5 (11.90%), ulcorraphy + Graham patch omentopexy in 29 (69.04%) and Heineke-Mikulicz pyloroplasty in 8 (19.04%) cases. Mortality was located at 16.66% associated with sepsis. It was concluded that the management of the perforated peptic ulcer was carried out mainly by ulcorraphy + Graham patch omentopexy, then by pyloroplasty, and lastly by simple ulcer closure. Keywords: Peptic Ulcer; Perforation; Surgery Management; Graham Patch; Ulcorraphy Introduction Peptic ulcer perforation is a life-threatening emergency that requires urgent surgical care [1]. Its intervention is very common in general surgery, however, if it is not performed in time, it can bring great repercussions such as septicemia or septic shock [2]. Peptic ulcer is generated when a circumscribed alteration occurs that involves the mucosa, submucosa and muscular layers [3]. Its pathophysiology is complex and includes several factors involved. Citation: Mariana Añolis., et al. “Perforated Peptic Ulcer: Surgical Management in the University Hospital of Maracaibo, Experience in 4 Years". Acta Scientific Gastrointestinal Disorders 4.11 (2021): 48-53. DOI: 10.31080/ASGIS.2022.05.0341