MEDITERRANEAN JOURNAL OF RHEUMATOLOGY 33 3 2022 316 This work is licensed under a Creative Commons Attribution 4.0 International License. ©El Ouardi N, Djossou HJ, Taoubane L, Ghassem AM, Toufk H, Majjad A, Sadni S, Hmamouchi I, Abouqal R,Bahiri R, Allali F, El Bouchti I, Ghozlani I, Hassikou H, Harzy T, Ichchou L, Mkinsi O, Niamane R, El Maghraoui A, Achemlal L. ABSTRACT Objectives: To describe and analyse the prevalence of extra-articular manifestations (EAMs) including acute anterior uveitis (AAU), psoriasis and infammatory bowel disease (IBD) in patients with ankylosing spondylitis (AS) in the Moroccan registry of biological therapies in rheumatic diseases RBSMR (Registre des Biothérapies de la Société Marocaine de Rhumatologie). Methods: A cross- sectional, multicentre and analytical study based on the RBSMR database, which included 170 AS. Incidence rates for the development of AAU, psoriasis and IBD were calculated, and risk factors were analysed. Results: Prevalence of EAMs in AS was 13.5%, 4.7% and 11.2% for AAU, psoriasis and IBD respectively. No signifcant diferences were found while establishing a comparison of the prevalence of these EAMs between AS patients with and without peripheral arthritis. Interestingly, AAU was the most common EAM, and was positively associated in multivariable regression with family history of spondyloarthritis (OR= 7.21, CI 95%: 2.23 -23.24). Conclusions: AAU was the leading EAM in patients with AS included in the Moroccan biotherapy registry (RBSMR) and it was associated with family history of spondyloarthritis. Mediterr J Rheumatol 2022;33(3):316-21 https://doi.org/10.31138/mjr.33.3.316 Article Submitted: 2 May 2021; Revised Form: 17 Jul 2021; Article Accepted: 30 Jul 2021; Available Online: 30 Sep 2022 Cite this article as: El Ouardi N, Djossou HJ, Taoubane L, Ghassem AM, Toufk H, Majjad A, Sadni S, Hmamouchi I, Abouqal R,Bahiri R, Allali F, El Bouchti I, Ghozlani I, Hassikou H, Harzy T, Ichchou L, Mkinsi O, Niamane R, El Maghraoui A, Achemlal L. Extra-Articular Manifestations in Patients with Ankylosing Spondylitis: Baseline Characteristics from the RBSMR Study. Mediterr J Rheumatol 2022;33(3):316-21. Keywords: ankylosing spondylitis, extra-articular manifestations, acute anterior uveitis, psoriasis, infammatory bowel disease Extra-Articular Manifestations in Patients with Ankylosing Spondylitis: Baseline Characteristics from the RBSMR Study Najlae El Ouardi 1 , Julien H. Djossou 1 , Laila Taoubane 1 , Mohamed A. Ghassem 1 , Hamza Toufk 1 , Abderrahim Majjad 1 , Siham Sadni 1 , Ihsane Hmamouchi 2,3* , Redouane Abouqal 2* , Rachid Bahiri 4* , Fadoua Allali 5* , Imane El Bouchti 6* , Imad Ghozlani 7* , Hasna Hassikou 8* , Taoufq Harzy 9* , Linda Ichchou 10* , Ouafa Mkinsi 11* , Redouane Niamane 12* , Abdellah El Maghraoui 13* , Lahsen Achemlal 1* *Members of the Scientifc Committee of the RBSMR study 1 Department of Rheumatology, Military Hospital Mohammed V, Ibn Sina University Hospital, Rabat, Morocco, 2 Laboratory of Biostatistical, Clinical and Epidemiological Research, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco, 3 Department of Rheumatology, Provincial Hospital of Temara, Morocco, 4 Department of Rheumatology A, El Ayachi Hospital, Ibn Sina University Hospital, Salé, Morocco, 5 Department of Rheumatology B, El Ayachi Hospital, Ibn Sina University Hospital, Salé, Morocco, 6 Department of Rheumatology, Arrazi University Hospital, Marrakech, Morocco, 7 Department of Rheumatology, University Hospital of Agadir, Morocco, 8 Department of Rheumatology, Military Hospital Moulay Ismail, Hassan II University Hospital, Meknès, Morocco, 9 Department of Rheumatology, Hassan II University Hospital, Fès, Morocco, 10 Department of Rheumatology, Mohammed VI University Hospital, Oujda, Morocco 11 Department of Rheumatology, Ibn Rochd University Hospital, Casablanca, Morocco, 12 Department of Rheumatology, Military Hospital Avicenne, Mohammed VI University Hospital, Marrakech, Morocco, 13 Private Medical Ofce, Rabat, Morocco Corresponding Author: Najlae El Ouardi Rheumatology Department, Military Hospital Mohammed V PO Box: 1018, Rabat, Morocco Tel./Fax: +212537716805 Tel.: +212641438067 E-mail: doc.najlae89@gmail.com ORIGINAL PAPER