4 Copyright © 2011 Korean Sleep Research Society ORIGINAL ARTICLE J Korean Sleep Res Soc 2011;8:4-8 ISSN 1738-608X Comparison of Sleep Quality and Polysomnographic Findings in Patients with RLS according to the Presence of Periodic Limb Movements during Sleep Mi-Yeon Eun, Hung Youl Seok, Jung Bin Kim and Ki-Young Jung Department of Neurology, Korea University College of Medicine, Seoul, Korea 하지불안증후군 환자에서 주기성 사지운동의 동반유무에 따른 수면의 질 및 수면다원검사 결과 비교 은미연, 석흥열, 김정빈, 정기영 고려대학교 의과대학 신경과학교실 Received May 13, 2011 Revised June 1, 2011 Accepted June 8, 2011 Address for correspondence Ki-Young Jung, MD Department of Neurology, Korea University College of Medicine, 126-1 Anam-dong 5-ga, Seongbuk-gu, Seoul 136-705, Korea Tel: +82-2-920-6649 Fax: +82-2-925-2472 E-mail: jungky@korea.ac.kr Objectives: Although it has been reported that periodic limb movements during sleep (PLMS) is present up to 80% in patients with restless legs syndrome (RLS), it is unclear that PLMS could infuence on sleep quality and excessive daytime sleepiness (EDS) in patient with RLS. To investigate infuence of PLMS on sleep quality and EDS, we analyzed sleep quality and EDS in patient with RLS. Methods: Fify fve RLS pa- tients were included in this study. RLS was diagnosed according to International Restless Legs Syndrome Study Group criteria. Patients were classifed into two groups according to the presence of PLMS. Group I (n=32) consisted of RLS patients without PLMS. Group II (n=23) consisted of RLS patients with PLMS. Te severity of RLS symptom was assessed using International RLS Study Group Rating Scale (IRLS). Sub- jective sleep quality was assessed by Pittsburgh Sleep Quality Index (PSQI), Athens Insomnia Scale (AIS), and Epworth Sleepiness Scale (ESS). Serum ferritin level and polysomnographic parameters were also com- pared between both groups. Results: Mean age was significantly higher in RLS patients with PLMS (p<0.05). IRLS, PSQI, ESS and AIS were not signifcantly diferent between groups. Among sleep parame- ters on polysomnography only PLM related variables were signifcantly higher in RLS patients with PLMS. Conclusions: Our study suggests that presence of PLMS in patient with RLS has no signifcant negative efect on sleep quality and excessive daytime sleepiness. J Korean Sleep Res Soc 2011;8:4-8 Key Words: Restless legs syndrome, Periodic limb movements, Sleep quality, Excessive daytime sleepiness, Polysomnography. 서 론 하지불안증후군(Restless legs syndrome)은 하지를 포함한 전신에 가만히 있을 때 발생하는 이상감각으로 정의되며 주 로 저녁 및 야간에 발생하거나 악화되면서, 움직임을 통해 해소되는 특징을 갖는다. 1 하지불안증후군은 감각운동증상 으로 정의되지만 임상적으로는 수면의 질 저하와 불면증, 주 간 졸음증 등에 의한 삶의 질 저하가 환자들의 주된 문제가 되고 2,3 수면장애 환자의 15% 가량을 차지할 만큼 수면장애 의 흔한 원인 중 하나이다. 하지불안증후군 환자의 수면양상 은 수면주기 중 1단계 수면이 많아지고 2단계 수면이 적어 지며, 수면주기에 잦은 변화를 보이고, 수면효율이 낮으며, 주 기성 사지운동지수와 주기성 사지운동관련 각성지수가 정상 대조군보다 유의하게 높은 양상을 보인다. 4 수면중 주기성 사지운동은 수면장애를 전혀 호소하지 않 는 정상인의 4~11%에서 관찰되고 5-7 연령이 증가함에 따라 서 그 빈도가 증가한다. 8-10 또한, 수면중 주기성 사지운동은 하지불안증후군에서 높은 동반율을 보이지만 렘수면행동장 애(REM sleep behavior disorder), 폐쇄성수면무호흡증 및 기면증 등 다른 수면질환에서도 자주 관찰이 된다. 4,11 수면중